Results 81 to 90 of about 1,802,430 (358)

CTCF regulates positioning of the human cystic fibrosis gene in association with a histone deacetylase

Genomics Data, 2014
The nuclear positioning of mammalian genes often correlates with their functional state. For instance, the human cystic fibrosis transmembrane conductance regulator (CFTR) gene associates with the nuclear periphery in its inactive state, but occupies ...
Joscha Muck
doaj   +1 more source

Recent advances in the functional explorations of nuclear microRNAs

Frontiers in Immunology, 2023
Approximately 22 nucleotide-long non-coding small RNAs (ncRNAs) play crucial roles in physiological and pathological activities, including microRNAs (miRNAs).
Xiaozhu Hu, Xiaozhu Hu, Guoquan Yin, Guoquan Yin, Yuan Zhang, Yuan Zhang, Liangyu Zhu, Liangyu Zhu, Haoyu Huang, Haoyu Huang, Kun Lv, Kun Lv   +11 more
doaj   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Regulated expression of CXCR4 constitutive active mutants revealed the up-modulated chemotaxis and up-regulation of genes crucial for CXCR4 mediated homing and engraftment of hematopoietic stem/progenitor cells

Journal of Stem Cells and Regenerative Medicine, 2013
SDF-1/CXCR4 axis plays a principle role in the homing and engraftment of hematopoietic stem/progenitor cells (HSPCs), a process that defines cells ability to reach and seed recipient bone marrow niche following their intravenous infusion.
Sharma M, Afrin F, Tripathi RP, Gangenahalli G   +3 more
doaj  

The gene encoding flavonol synthase contributes to lesion mimic in wheat

Crop Journal
Lesion mimic often exhibits leaf disease-like symptoms even in the absence of pathogen infection, and is characterized by a hypersensitive-response (HR) that closely linked to plant disease resistance.
Tingting Dong, Hongchun Xiong, Huijun Guo, Yongdun Xie, Linshu Zhao, Jiayu Gu, Huiyuan Li, Shirong Zhao, Yuping Ding, Xiyun Song, Luxiang Liu   +10 more
doaj   +1 more source

Nuclear glycolytic enzyme enolase of Toxoplasma gondii functions as a transcriptional regulator. [PDF]

PLoS ONE, 2014
Apicomplexan parasites including Toxoplasma gondii have complex life cycles within different hosts and their infectivity relies on their capacity to regulate gene expression.
Thomas Mouveaux, Gabrielle Oria, Elisabeth Werkmeister, Christian Slomianny, Barbara A Fox, David J Bzik, Stanislas Tomavo   +6 more
doaj   +1 more source

Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. [PDF]

, 1994
To study the functions of heterogeneous nuclear ribonucleoproteins (hnRNPs), we have characterized nuclear polyadenylated RNA-binding (Nab) proteins from Saccharomyces cerevisiae.
Datar, KV, Paddy, MR, Swanson, MS, Swedlow, JR, Wilson, SM   +4 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Nuclear miRNAs: gene regulation activities

International Journal of Molecular Sciences
MicroRNAs are small non-coding RNAs, which contribute to the regulation of many physiolog-ical and pathological processes. Conventionally, miRNAs perform their activity in the cyto-plasm, where they regulate gene expression by interacting in a sequence-specific manner with mature messenger RNAs.
Monia Billi, Elisabetta De Marinis, Martina Gentile, Clara Nervi, Francesco Grignani   +4 more
openaire   +2 more sources

Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

PLoS Genetics, 2014
Recent interest has focused on the importance of the nucleus and associated nucleoskeleton in regulating changes in cardiac gene expression in response to biomechanical load.
Indroneal Banerjee, Jianlin Zhang, Thomas Moore-Morris, Emily Pfeiffer, Kyle S Buchholz, Ao Liu, Kunfu Ouyang, Matthew J Stroud, Larry Gerace, Sylvia M Evans, Andrew McCulloch, Ju Chen   +11 more
doaj   +1 more source