Results 81 to 90 of about 1,892,385 (358)

Nuclear compartmentalization of odorant receptor genes [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance The mechanisms underlying odorant receptor (OR) monoallelic and monogenic expression are unclear. We show for the first time that the nuclei of olfactory neurons have a characteristic organization of facultative heterochromatin: it is highly concentrated around a large constitutive heterochromatin block located centrally in the ...
Lucia M, Armelin-Correa, Luciana M, Gutiyama, Débora Y C, Brandt, Bettina, Malnic   +3 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The gene encoding flavonol synthase contributes to lesion mimic in wheat

Crop Journal
Lesion mimic often exhibits leaf disease-like symptoms even in the absence of pathogen infection, and is characterized by a hypersensitive-response (HR) that closely linked to plant disease resistance.
Tingting Dong, Hongchun Xiong, Huijun Guo, Yongdun Xie, Linshu Zhao, Jiayu Gu, Huiyuan Li, Shirong Zhao, Yuping Ding, Xiyun Song, Luxiang Liu   +10 more
doaj   +1 more source

The gateway to chloroplast: re-defining the function of chloroplast receptor proteins [PDF]

, 2012
Chloroplast biogenesis often requires a tight orchestration between gene expression (both plastidial and nuclear) and translocation of similar to 3000 nuclear-encoded proteins into the organelle.
Bölter, Bettina, Chang, Wai-Ling, Soll, Jürgen   +2 more
core   +1 more source

Gene silencing at the nuclear periphery [PDF]

The FEBS Journal, 2007
The nuclear envelope (NE) is composed of inner and outer nuclear membranes (INM and ONM, respectively), nuclear pore complexes and an underlying mesh like supportive structure – the lamina. It has long been known that heterochromatin clusters at the nuclear periphery adjacent to the nuclear lamina, hinting that proteins of the lamina may participate in
Sigal, Shaklai, Ninette, Amariglio, Gideon, Rechavi, Amos J, Simon   +3 more
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Nuclear glycolytic enzyme enolase of Toxoplasma gondii functions as a transcriptional regulator. [PDF]

PLoS ONE, 2014
Apicomplexan parasites including Toxoplasma gondii have complex life cycles within different hosts and their infectivity relies on their capacity to regulate gene expression.
Thomas Mouveaux, Gabrielle Oria, Elisabeth Werkmeister, Christian Slomianny, Barbara A Fox, David J Bzik, Stanislas Tomavo   +6 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Fibroblast growth factors induce hepatic tumorigenesis post radiofrequency ablation

Scientific Reports, 2023
Image-guided radiofrequency ablation (RFA) is used to treat focal tumors in the liver and other organs. Despite potential advantages over surgery, hepatic RFA can promote local and distant tumor growth by activating pro-tumorigenic growth factor and ...
Aurelia Markezana, Mor Paldor, Haixing Liao, Muneeb Ahmed, Elina Zorde-Khvalevsky, Nir Rozenblum, Matthias Stechele, Lukas Salvermoser, Flinn Laville, Salome Goldmann, Nofar Rosenberg, Tomas Andrasina, Jens Ricke, Eithan Galun, Shraga Nahum Goldberg   +14 more
doaj   +1 more source

Relationship between p53 expression and gastric cancers in cardia and antrum [PDF]

, 2008
Background: The mutations in p53 gene and accumulation of p53 protein are the most common genetic events in gastric carcinomas. The present study was conducted to compare the frequency of p53 gene overexpression in a consecutive series of adenocarcinomas
Amiriani, T., Azarhoush, R., Kazemi-Nejad, V., Keshtkar, A.A.   +3 more
core