Results 121 to 130 of about 270,346 (298)

Nuclear import of factors involved in signaling is inhibited in C3H/10T1/2 cells treated with tetradecylthioacetic acid

Journal of Lipid Research, 2002
The non-β-oxidisable tetradecylthioacetic acid (TTA) is incorporated into cellular membranes when C3H/10T1/2 cells are cultured in TTA-containing medium.
Bodil Bjørndal, Charlotte Helleland, Stig-Ove Bøe, Oddrun A. Gudbrandsen, Karl-Henning Kalland, Pavol Bohov, Rolf K. Berge, Johan R. Lillehaug   +7 more
doaj   +1 more source

LFA: A Lattice Fourier Analyzer for Quantitative In Situ EC‐STM of Adsorbate–Substrate Superstructures

Advanced Materials Interfaces, EarlyView.
Although electrochemical scanning tunneling microscopy provides atomic‐scale access to electrified interfaces, quantitative in situ and operando investigations suffer from drift‐induced distortions. This work introduces the Lattice Fourier Analyzer (LFA), which employs substrate‐anchored affine drift correction in reciprocal space to recover precise ...
Rafał Lewandków, Paulina Wira, Anna Futyma, Radosław Wasielewski, Tomasz Kosmala   +4 more
wiley   +1 more source

TNPO2 operates downstream of DYNC1I1 and promotes gastric cancer cell proliferation and inhibits apoptosis

Cancer Medicine, 2019
The import of proteins into the nucleus plays an important role in tumor development. In addition to the classical nuclear import proteins importin‐β and importin‐α, there are many nonclassical nuclear import proteins that include TNPO2.
Libao Gong, Ti Wen, Zhi Li, Yizhe Wang, Jin Wang, Xiaofang Che, Yunpeng Liu, Xiujuan Qu   +7 more
doaj   +1 more source

Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila

Neurobiology of Disease, 2015
Inclusions containing Fused in Sarcoma (FUS) are found in familial and sporadic cases of the incurable progressive motor neuron disease amyotrophic lateral sclerosis and in a common form of dementia, frontotemporal dementia.
Sandra Jäckel, Anna K. Summerer, Catherine M. Thömmes, Xia Pan, Aaron Voigt, Jörg B. Schulz, Tobias M. Rasse, Dorothee Dormann, Christian Haass, Philipp J. Kahle   +9 more
doaj   +1 more source

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, EarlyView.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source

3D‐Nanoprinted Fluidically Steerable Soft Robotic Microcatheters

Advanced Robotics Research, EarlyView.
This work introduces a ∼3‐French (1 mm‐in‐diameter) soft robotic microcatheter fabricated by means of two‐photon direct laser writing. The 3D‐printed microcatheter enables remote, on‐demand steering via microfluidic actuation for guidewire‐free navigation of vascular networks as well as microcatheter‐mediated delivery of fluidic payloads to target ...
Bailey M. Felix, Molly Carton, Olivia M. Young, Noah Barnes, Jordi T. Andreou, Sarah McHugh, Jack E. McCann, Claudia Davis, Victoria Reddig‐Leiman, Afsah Kamran, Dheeraj Gandhi, Miroslaw Janowski, Jeremy D. Brown, Mark Fuge, Axel Krieger, Clifford R. Weiss, Christopher R. Bailey, Ryan D. Sochol   +17 more
wiley   +1 more source

Yeast karyopherin Kap95 is required for cell cycle progression at Start

BMC Cell Biology, 2010
Background The control of the subcellular localization of cell cycle regulators has emerged as a crucial mechanism in cell division regulation. The active transport of proteins between the nucleus and the cytoplasm is mediated by the transport receptors ...
Igual Juan, Taberner Francisco
doaj   +1 more source

Nuclear Ensemble Approach with Importance Sampling

Journal of Chemical Theory and Computation, 2018
We show that the importance sampling technique can effectively augment the range of problems where the nuclear ensemble approach can be applied. A sampling probability distribution function initially determines the collection of initial conditions for which calculations are performed, as usual.
Kossoski, Fábris, Barbatti, Mario
openaire   +4 more sources

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source