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The nuclear lamina comes of age
Nature Reviews Molecular Cell Biology, 2005Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins, nesprins and SUN-domain proteins. These complexes have roles in chromatin organization, gene regulation and signal transduction. Some link the nucleoskeleton to cytoskeletal structures, ensuring that the nucleus and centrosome assume appropriate intracellular positions.
Katherine L. Wilson +4 more
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The nuclear lamina and inherited disease
Trends in Cell Biology, 2002Inherited disorders of the nuclear lamina present some of the most intriguing puzzles in cell biology. Mutations in lamin A and lamin C - nuclear intermediate filament proteins that are expressed in nearly all somatic cells - cause tissue-specific diseases that affect striated muscle, adipose tissue and peripheral nerve or skeletal development.
Jean-Claude Courvalin, Howard J. Worman
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Assembly-disassembly of the nuclear lamina
Current Opinion in Cell Biology, 1992Recently, progress in the study of lamins has been made in three areas: signals required for targetting newly synthesized lamins to the correct subnuclear compartment have been identified; information on lamina assembly has been obtained from in vitro studies using bacterially expressed proteins; and a mechanistic explanation for how the nuclear lamina
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Immunological analysis of nuclear lamina proteins
Chromosoma, 1980Antibodies have been obtained against specific fractions of the nuclear lamina from chick red blood cells. Immunofluorescent staining of acrylamide gels from nuclear lamina preparations revealed a spectrum of at least 8-10 proteins cross-reacting immunologically with each other.
Peter Hausen, Reimer Stick
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The nuclear lamina and heterochromatin: a complex relationship
Biochemical Society Transactions, 2011In metazoan cells, the heterochromatin is generally localized at the nuclear periphery, whereas active genes are preferentially found in the nuclear interior. In the present paper, we review current evidence showing that components of the nuclear lamina interact directly with heterochromatin, which implicates the nuclear lamina in a mechanism of ...
Yosef Gruenbaum, Erin M. Bank
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The Role of the Nuclear Lamina in Cancer and Apoptosis
2014Not long after the discovery of lamin proteins, it became clear that not all lamin subtypes are ubiquitously expressed in cells and tissues. Especially, A-type lamins showed an inverse correlation with proliferation and were thus initially called statins.
Jos L. V. Broers, Frans C. S. Ramaekers
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Nuclear lamina and organization of nuclear architecture
Trends in Biochemical Sciences, 1986Abstract The nuclear lamina is a polymeric protein meshwork that lines the nucleoplasmic surface of the nuclear envelope. Recent work demonstrates that the lamina is composed of intermediate-type filaments, one of the major classes of structural filaments in cells.
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Mechanisms of nuclear lamina growth in interphase
Histochemistry and Cell Biology, 2016The nuclear lamina represents a multifunctional platform involved in such diverse yet interconnected processes as spatial organization of the genome, maintenance of mechanical stability of the nucleus, regulation of transcription and replication. Most of lamina activities are exerted through tethering of lamina-associated chromatin domains (LADs) to ...
Varvara D. Cherepanynets +6 more
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A new model for nuclear lamina organization
Biochemical Society Transactions, 2008Lamins are intermediate filament proteins that form a network lining the inner nuclear membrane. They provide mechanical strength to the nuclear envelope, but also appear to have many other functions as reflected in the array of diseases caused by lamin mutations.
Reimer Stick +3 more
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Organization and modulation of nuclear lamina structure
Journal of Cell Science, 1984ABSTRACT The nuclear lamina is a protein meshwork associated with the nucleoplasmic surface of the inner nuclear membrane, that is suggested to be important for organizing nuclear envelope and interphase chromosome architecture. To investigate the structural organization of the lamina, we have analysed rat liver nuclear envelopes by ...
Larry Gerace +2 more
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