Results 1 to 10 of about 6,030,389 (286)

Nuclear Shape-Shifters: Lipid and Protein Dynamics at the Nuclear Envelope

open access: yesCells, 2022
The nuclear envelope constitutes a selective barrier that segregates chromatin into the nucleus of eukaryotic cells [...]
Wolfram Antonin, Symeon Siniossoglou
doaj   +4 more sources

The potential role of hydrogen sulfide in cancer cell apoptosis

open access: yesCell Death Discovery
For a long time, hydrogen sulfide (H2S) has been considered a toxic compound, but recent studies have found that H2S is the third gaseous signaling molecule which plays a vital role in physiological and pathological conditions.
Wei Gao   +9 more
doaj   +1 more source

The monkeypox diagnosis, treatments and prevention: A review

open access: yesFrontiers in Cellular and Infection Microbiology, 2023
The world is currently dealing with a second viral outbreak, monkeypox, which has the potential to become an epidemic after the COVID-19 pandemic.
Saadullah Khattak   +7 more
doaj   +1 more source

Fragment-Based Approaches Identified Tecovirimat-Competitive Novel Drug Candidate for Targeting the F13 Protein of the Monkeypox Virus

open access: yesViruses, 2023
Monkeypox is a serious public health issue in tropical and subtropical areas. Antivirals that target monkeypox proteins might lead to more effective and efficient therapy. The F13 protein is essential for the growth and maturation of the monkeypox virus.
Yasir Ali   +8 more
doaj   +1 more source

Phage Henu12-resistant mutant derives fitness trade-offs in Shigella dysenteriae

open access: yesMicrobiology Spectrum
The rapid emergence of multidrug-resistant Shigella dysenteriae strains necessitates new therapeutic approaches, such as phage therapy. Phages are considered a promising adjunct to antibiotics.
Salwa E. Gomaa   +14 more
doaj   +1 more source

Rho-Kinase Inhibitors as Emerging Targets for Glaucoma Therapy

open access: yesOphthalmology and Therapy, 2023
Glaucoma, the leading cause of irreversible blindness worldwide, is a chronic and progressive optic neuropathy characterized by damage to the optic and retinal nerve fiber layers, which can lead to permanent loss of peripheral or central vision ...
Jun Wang, Hanke Wang, Yalong Dang
doaj   +1 more source

The therapeutic prospects of N-acetylgalactosamine-siRNA conjugates

open access: yesFrontiers in Pharmacology, 2022
RNA interference has become increasingly used for genetic therapy following the rapid development of oligonucleotide drugs. Significant progress has been made in its delivery system and implementation in the treatment of target organs.
Lei Zhang   +6 more
doaj   +1 more source

Assessment of General Populations Knowledge, Attitude, and Perceptions Toward the Coronavirus Disease (COVID-19): A Cross-Sectional Study From Pakistan

open access: yesFrontiers in Medicine, 2021
Background: Coronavirus disease 2019 (COVID-19) is a global health threat and caused a universal psychosocial impact on the general population. Therefore, the knowledge, attitude, and perceptions (KAPs) of the general population are critical for the ...
Saadullah Khattak   +16 more
doaj   +1 more source

Role of hydrogen sulfide in health and disease

open access: yesMedComm
In the past, hydrogen sulfide (H2S) was recognized as a toxic and dangerous gas; in recent years, with increased research, we have discovered that H2S can act as an endogenous regulatory transmitter.
Yu‐Qing Jin   +9 more
doaj   +1 more source

Transposons disrupt genomic stability and trigger cancers

open access: yesFrontiers in Cellular and Infection Microbiology
Transposons (TEs) are genetic elements that can change their positions within genome. They cause transcriptional activation or repression by inserting into regulatory elements of related genes or by modulating epigenetic modifications on regulatory ...
Weixia Dong   +7 more
doaj   +1 more source

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