Tissue mechanics modulate PCNP expression in oral squamous cell carcinomas with different differentiation [PDF]
Frontiers in Oncology, 2023 BackgroundPEST-containing nuclear protein (PCNP), a novel zinc finger protein, participates in cell cycle regulation. Previous studies have confirmed that PCNP plays a role in mediating cellular development and invasion in a variety of cancer types ...
Leyang Zhang +13 more
exaly +6 more sources
LINC00858 promotes colon cancer progression through activation of STAT3/5 signaling by recruiting transcription factor RAD21 to upregulate PCNP [PDF]
Cell Death Discovery, 2022 The purpose of our investigation is to explore the putative molecular mechanisms underpinning LINC00858 involvement in colon cancer. The expression of LINC00858 in TCGA data was identified using the GEPIA website.
Ting Xu, Guoquan Tao, Shutao Zheng
exaly +5 more sources
PCNP promotes hepatocellular carcinoma progression by upregulating UHRF2 to activate ErbB3/Ras/Raf pathway [PDF]
Scientific ReportsThe PEST-containing nuclear protein (PCNP) has been reported to play paradoxical roles in tumorigenesis. While PCNP functions as a tumor suppressor in neuroblastoma and lung adenocarcinoma, it has been identified as a tumor promoter in ovarian cancer ...
Jinlong Luo +3 more
exaly +4 more sources
Biology of PEST‐Containing Nuclear Protein: A Potential Molecular Target for Cancer Research [PDF]
Frontiers in Oncology, 2022 PEST-containing nuclear protein (PCNP), a novel nuclear protein, is involved in vital cellular processes like cell proliferation and mediates tumorigenesis.
Nazeer Hussain Khan +2 more
exaly +4 more sources
The role and potential mechanism of PEST-containing nuclear protein (PCNP) in endothelial cell angiogenesis in vitro [PDF]
Scientific ReportsRetinal neovascularization (RNV) is a pathological hallmark of vision-threatening diseases such as diabetic retinopathy. Current therapies targeting vascular endothelial growth factors (VEGF) have limitations, highlighting the need for novel therapeutic ...
Yalong Dang
exaly +3 more sources
Taking a holistic view of PEST‐containing nuclear protein (PCNP) in cancer biology [PDF]
Cancer Medicine, 2019 Polypeptide sequences enriched with proline (P), glutamic acid (E), aspartic acid (D) and serine (S)/ threonine (T) (PEST) have been reported to be the most abundant and frequently distributed at the cellular level.
Attia Afzal +2 more
exaly +4 more sources
p-Coumaric Acid Nanoparticles Ameliorate Diabetic Nephropathy via Regulating mRNA Expression of KIM-1 and GLUT-2 in Streptozotocin-Induced Diabetic Rats [PDF]
Metabolites, 2022 Diabetic nephropathy (DN) has become a leading cause of end-stage renal failure worldwide. The goal of the current study was to examine the protective effects of chitosan-loaded p-Coumaric acid nanoparticles (PCNPs) in nephrotoxicity induced by ...
Amalan Venkatesan +4 more
doaj +2 more sources
Preparation and Performance of Phthalocyanine @ Copper Iodide Cluster Nanoparticles for X-Ray-Induced Photodynamic Therapy [PDF]
MoleculesThe efficacy of X-ray-induced photodynamic therapy (X-PDT) for deep tumors is often hindered by conventional scintillators, typically rare-earth nanoparticles plagued by long-term toxicity and suboptimal scintillation yields.
Wei Xie +7 more
doaj +2 more sources
siAKR1C3@PPA complex nucleic acid nanoparticles inhibit castration-resistant prostate cancer in vitro [PDF]
Frontiers in Oncology, 2022 IntroductionAKR1C3, as a crucial androgenic enzyme, implicates the androgen biosynthesis and promoting prostate cancer cell growth in vitro. This study provides a new gene therapy strategy for targeting AKR1C3 to treat castration-resistant prostate ...
Xiaoli Cui +10 more
doaj +2 more sources
Weight analysis of Chinese nurses' behaviors to maintain patient dignity and its relationship with job-esteem: a cross-sectional study controlling for agreeableness [PDF]
Frontiers in PsychologyBackgroundPatient dignity is fundamental to nursing ethics and care quality, yet nurses often face challenges in upholding it. This study examines how nurses' Job-Esteem influences their behaviors for maintaining patient dignity in China.MethodsThis two ...
Cong Guo +8 more
doaj +2 more sources