Results 21 to 30 of about 768 (137)

siAKR1C3@PPA complex nucleic acid nanoparticles inhibit castration-resistant prostate cancer in vitro [PDF]

Frontiers in Oncology, 2022
IntroductionAKR1C3, as a crucial androgenic enzyme, implicates the androgen biosynthesis and promoting prostate cancer cell growth in vitro. This study provides a new gene therapy strategy for targeting AKR1C3 to treat castration-resistant prostate ...
Xiaoli Cui, Zhou Yao, Tianyu Zhao, Jiahui Guo, Jipeng Ding, Siwei Zhang, Zuowen Liang, Zhengren Wei, Alexis Zoa, Yuantong Tian, Jing Li   +10 more
doaj   +2 more sources

Weight analysis of Chinese nurses' behaviors to maintain patient dignity and its relationship with job-esteem: a cross-sectional study controlling for agreeableness [PDF]

Frontiers in Psychology
BackgroundPatient dignity is fundamental to nursing ethics and care quality, yet nurses often face challenges in upholding it. This study examines how nurses' Job-Esteem influences their behaviors for maintaining patient dignity in China.MethodsThis two ...
Cong Guo, Chunlin Zhang, Cuizhu Zhou, Mengqi Zhu, Lingling Chen, Youran Liu, Yequn Zhang, Jie Wang, Tengfei Liang   +8 more
doaj   +2 more sources

Biologically Targeted Photo‐Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion [PDF]

Advanced Science, 2019
Peritoneal adhesion occurs in a majority of patients following abdominal surgery and can result in significant side effects and complications. Current strategies to minimize adhesions involve the use of nontargeted anatomical barriers that are either ...
Yu Mi, Feifei Yang, Cameron Bloomquist, Youli Xia, Bo Sun, Yanfei Qi, Kyle Wagner, Stephanie A. Montgomery, Tian Zhang, Andrew Z. Wang   +9 more
doaj   +2 more sources

The potential relationship between YAP and PCNP in esophageal carcinoma and its influence on carcinogenesis

Gene & Protein in Disease
Esophageal cancer is one of the malignant tumors with high incidence and mortality rates worldwide. Its occurrence and development involve abnormal regulation of multiple signaling pathways. In recent years, the role of Hippo signaling and PEST-containing nuclear protein (PCNP) in esophageal cancer has gradually received attention.
Weihang Sun, Faji Liu, Tiantian Sun, Xu Han, Junru Jia, Haiqiang Wang, Xinying Ji, Yang An, Junhui Guo   +8 more
exaly   +2 more sources

Identification of Tumor-Suppressive miR-30a-3p Controlled Genes: ANLN as a Therapeutic Target in Breast Cancer [PDF]

Non-Coding RNA
Our recently created RNA-sequence-based microRNA (miRNA) expression signature in breast cancer clinical specimens revealed that some miR-30 family members were significantly downregulated in cancer tissues.
Reiko Mitsueda, Ayako Nagata, Hiroko Toda, Yuya Tomioka, Ryutaro Yasudome, Mayuko Kato, Yoshiaki Shinden, Akihiro Nakajo, Naohiko Seki   +8 more
doaj   +2 more sources

Study on biomarkers of homocysteine-induced transformation of vascular smooth muscle cells into foam cells [PDF]

Scientific Reports
Homocysteine (Hcy) is an independent risk factor for atherosclerosis (AS). Hcy induces the transformation of vascular smooth muscle cells (VSMCs) into foam cells, which play a crucial role in this process. However, the detailed mechanism is still unclear.
Xiuyu Wang, Xinpeng Ma, Xiang Zhang, Xing Ma, Minghao Zhang   +4 more
doaj   +2 more sources

Polycationic Peptide Engineering of Phage Endolysins Expands Host Range and Enhances Antibacterial and Antibiofilm Activities Against Bacillus Species. [PDF]

Biotechnol Bioeng
ABSTRACT The exponential rise in antimicrobial resistance has highlighted the urgent need for the development of alternative antibacterial strategies, including phage‐derived and engineered protein agents such as endolysins and artilysins. In this study, we report the rational design, expression, and functional characterization of novel artilysins ...
Ansari F, Tarushi, Nagar V.
europepmc   +2 more sources

Platinum-Catalysed Hydrofluorination of Alkynes at Room Temperature Promoted by a Fluoride Shuttle. [PDF]

Angew Chem Int Ed Engl
This work presents an air and moisture tolerant platinum‐catalysed hydrofluorination system that gives selectively (Z)‐fluoroalkenes. Experimental and computational investigation on the mechanism allowed for the identification of catalytic species. The hydrofluorination is mediated by complexes between the fluorinated anion and HF, resulting into BF3 ...
He O, Jameel F, Flammang H, Babu SS, Kaupp M, Braun T.   +5 more
europepmc   +3 more sources

Routes to Cyclobutadiene and Cycloallyl Pt(II) Complexes: Dicationic Bis(Alkyne) Species as Intermediates. [PDF]

Chemistry
This work demonstrates the synthesis of cationic Pt(II) η3‐cycloallyl complexes, and experimental and computational studies show a ligand bite‐angle dependence of their formation rates. The reactivity of these complexes with Brønsted acids was investigated, leading to the formation of cationic and dicationic Pt(II) η4‐cyclobutadiene complexes ...
He O, Jameel F, Stampehl YEH, Richter LM, Tosi M, Kaupp M, Braun T.   +6 more
europepmc   +2 more sources

Septic Shock and Prognosis in Dogs and Cats With Sepsis-Consensus Definition and Clinical Criteria. [PDF]

J Vet Emerg Crit Care (San Antonio)
ABSTRACT Death from sepsis results from progressive organ dysfunction. Early recognition of increased illness severity or deterioration in clinical status enables timely interventions that can improve outcomes. We aimed to define septic shock by consensus and to use the existing literature to identify associated clinical and clinicopathologic ...
Goggs R, Cortellini S, DeClue AE, Giunti M, Hopper K, Menard JM, Rabelo RC, Rozanski EA, Sharp CR, Silverstein DC, Sinnott-Stutzman V, Stanzani G, Bourgeois J, Fausak E.   +13 more
europepmc   +2 more sources