Results 11 to 20 of about 768 (137)

Evaluation of Serum NT-pCNP as a Diagnostic and Prognostic Biomarker for Sepsis in Dogs [PDF]

Journal of Veterinary Internal Medicine, 2011
Abstract Background There is a need for diagnostic biomarkers that can rapidly differentiate dogs with sepsis from dogs with noninfectious forms of systemic inflammatory response syndrome (NSIRS).
Claire R Sharp, Amy E DeClue
exaly   +5 more sources

Regulation of PEST-containing nuclear proteins in cancer cells: implications for cancer biology and therapy [PDF]

Frontiers in Oncology
The PEST-containing nuclear protein (PCNP) is a nuclear protein involved in the regulation of cell cycle progression, protein degradation, and tumorigenesis. PCNP contains a PEST sequence, a polypeptide structural motif rich in proline (P), glutamic acid
Xin-Ying Ji, Zhi-Liang Jiang
exaly   +4 more sources

NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST‐containing nuclear protein [PDF]

FEBS Letters, 2003
We previously reported the association of a novel Np95/ICBP90‐like RING finger protein (NIRF) with a novel PEST‐containing nuclear protein (PCNP). NIRF is a nuclear protein with a ubiquitin‐like domain, a PHD finger, a YDG/SRA domain, Rb‐binding motifs and a RING finger.
Mori, Tsutomu, Li, Yuanyuan, Hata, Hiroaki, Kochi, Hideo   +3 more
openaire   +4 more sources

PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways

BMC Cancer, 2018
Background PEST-containing nuclear protein (PCNP), a novel nuclear protein, is involved in cell proliferation and tumorigenesis. However, the precise mechanism of action of PCNP in the process of tumor growth has not yet been fully elucidated.
Dong-Dong Wu, Ying-Ran Gao, Tao Li, Da-Yong Wang, Dan Lu, Shi-Yu Liu, Ya Hong, Hui-Bin Ning, Jun-Ping Liu, Jia Shang, Jun-Feng Shi, Jian-She Wei, Xin-Ying Ji   +12 more
doaj   +2 more sources

Increased Loading, Efficacy and Sustained Release of Silibinin, a Poorly Soluble Drug Using Hydrophobically-Modified Chitosan Nanoparticles for Enhanced Delivery of Anticancer Drug Delivery Systems

Nanomaterials, 2017
Conventional delivery of anticancer drugs is less effective due to pharmacological drawbacks such as lack of aqueous solubility and poor cellular accumulation. This study reports the increased drug loading, therapeutic delivery, and cellular accumulation
Cha Yee Kuen, Sharida Fakurazi, Siti Sarah Othman, Mas Jaffri Masarudin   +3 more
doaj   +3 more sources

A Tale of Grass and Trees: Characterizing Vegetation Change in Payne’s Creek National Park, Belize from 1975 to 2019

Applied Sciences, 2020
The lowland savannas of Belize are important areas to conserve for their biodiversity. This study takes place in Payne’s Creek National Park (PCNP) in the southern coastal plain of Belize.
Luke Blentlinger, Hannah V. Herrero
doaj   +2 more sources

p-Coumaric Acid Nanoparticles Ameliorate Diabetic Nephropathy via Regulating mRNA Expression of KIM-1 and GLUT-2 in Streptozotocin-Induced Diabetic Rats [PDF]

Metabolites, 2022
Diabetic nephropathy (DN) has become a leading cause of end-stage renal failure worldwide. The goal of the current study was to examine the protective effects of chitosan-loaded p-Coumaric acid nanoparticles (PCNPs) in nephrotoxicity induced by ...
Amalan Venkatesan, Anitha Roy, Srinivasan Kulandaivel, Vijayakumar Natesan, Sung-Jin Kim   +4 more
doaj   +2 more sources

PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition

Journal of Cellular and Molecular Medicine, 2020
AbstractEver reports showed that PCNP is associated with human cancers including neuroblastoma and lung cancer. However, the role and underlying molecular mechanism of PCNP in ovarian cancer have not been plenty elucidated. Herein, we first investigated the expression of PCNP in ovarian cancer tissues and cells, the effects of PCNP in ovarian cancer ...
Xin Zhang, Dongdong Wu, Huimin Li
exaly   +3 more sources

TIPE2 and PCNP expression abnormalities in peripheral blood mononuclear cells associated with disease activity in rheumatoid arthritis: a meta-analysis.

European Review for Medical and Pharmacological Sciences, 2021
Rheumatoid arthritis (RA) is a prevalent chronic autoimmune disease posing a considerable burden on both individuals and society. Tumor necrosis induced protein 8-like 2 (TIPE2), closely related to PEST-containing nuclear protein (PCNP) expression, is an immune-related protein potentially involved in the pathogenesis of autoimmune diseases.
H-Y Chen
exaly   +3 more sources

Preparation and Performance of Phthalocyanine @ Copper Iodide Cluster Nanoparticles for X-Ray-Induced Photodynamic Therapy [PDF]

Molecules
The efficacy of X-ray-induced photodynamic therapy (X-PDT) for deep tumors is often hindered by conventional scintillators, typically rare-earth nanoparticles plagued by long-term toxicity and suboptimal scintillation yields.
Wei Xie, Yunan Li, Guoyan Tang, Zhihua Li, Mengyu Yao, Biyuan Zheng, Xingshu Li, Jian-Dong Huang   +7 more
doaj   +2 more sources