Results 11 to 20 of about 1,691 (152)

PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer [PDF]

International Journal of Biological Sciences, 2022
Thyroid cancer (TC) has increased globally, with a prominent increase in small, papillary thyroid cancers. PEST-containing nuclear protein (PCNP), a nuclear protein, has been found to be associated with human cancers in recent years. However, the role and molecular mechanism of PCNP in thyroid cancer remain underexplored.
Dongdong Wu, Xin-Ying Ji
exaly   +4 more sources

Evaluation of Serum NT‐pCNP as a Diagnostic and Prognostic Biomarker for Sepsis in Dogs [PDF]

Journal of Veterinary Internal Medicine, 2011
Background: There is a need for diagnostic biomarkers that can rapidly differentiate dogs with sepsis from dogs with noninfectious forms of systemic inflammatory response syndrome (NSIRS). Objectives: To compare serum NT‐pCNP concentrations among dogs
Bigio, A., DeClue, A.E., Osterbur, K., Sharp, C.R.   +3 more
exaly   +6 more sources

PCNP promotes ovarian cancer progression by accelerating β‐catenin nuclear accumulation and triggering EMT transition [PDF]

Journal of Cellular and Molecular Medicine, 2020
AbstractEver reports showed that PCNP is associated with human cancers including neuroblastoma and lung cancer. However, the role and underlying molecular mechanism of PCNP in ovarian cancer have not been plenty elucidated. Herein, we first investigated the expression of PCNP in ovarian cancer tissues and cells, the effects of PCNP in ovarian cancer ...
Xin Zhang, Huimin Li, Dongdong Wu
exaly   +4 more sources

PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways

BMC Cancer, 2018
Background PEST-containing nuclear protein (PCNP), a novel nuclear protein, is involved in cell proliferation and tumorigenesis. However, the precise mechanism of action of PCNP in the process of tumor growth has not yet been fully elucidated.
Dongdong Wu, Xin-Ying Ji
exaly   +3 more sources

Identification of Tumor-Suppressive miR-30a-3p Controlled Genes: ANLN as a Therapeutic Target in Breast Cancer [PDF]

Non-Coding RNA
Our recently created RNA-sequence-based microRNA (miRNA) expression signature in breast cancer clinical specimens revealed that some miR-30 family members were significantly downregulated in cancer tissues.
Reiko Mitsueda, Ayako Nagata, Hiroko Toda, Yuya Tomioka, Ryutaro Yasudome, Mayuko Kato, Yoshiaki Shinden, Akihiro Nakajo, Naohiko Seki   +8 more
doaj   +2 more sources

Study on biomarkers of homocysteine-induced transformation of vascular smooth muscle cells into foam cells [PDF]

Scientific Reports
Homocysteine (Hcy) is an independent risk factor for atherosclerosis (AS). Hcy induces the transformation of vascular smooth muscle cells (VSMCs) into foam cells, which play a crucial role in this process. However, the detailed mechanism is still unclear.
Xiuyu Wang, Xinpeng Ma, Xiang Zhang, Xing Ma, Minghao Zhang   +4 more
doaj   +2 more sources

Platinum-Catalysed Hydrofluorination of Alkynes at Room Temperature Promoted by a Fluoride Shuttle. [PDF]

Angew Chem Int Ed Engl
This work presents an air and moisture tolerant platinum‐catalysed hydrofluorination system that gives selectively (Z)‐fluoroalkenes. Experimental and computational investigation on the mechanism allowed for the identification of catalytic species. The hydrofluorination is mediated by complexes between the fluorinated anion and HF, resulting into BF3 ...
He O, Jameel F, Flammang H, Babu SS, Kaupp M, Braun T.   +5 more
europepmc   +3 more sources

Genetic Encoding of Cyanopyridylalanine for In-Cell Protein Macrocyclization by the Nitrile-Aminothiol Click Reaction. [PDF]

Angew Chem Int Ed Engl, 2022
Genetic encoded cyanopyridylalanines are presented as convenient and highly selective reactive groups for in vivo functionalization, cyclization and stapling of polypeptides. The non‐toxic compounds can be genetically incorporated into proteins with high yields and their biocompatible reaction with amino‐thiol moieties proceeds under physiological ...
Abdelkader EH, Qianzhu H, George J, Frkic RL, Jackson CJ, Nitsche C, Otting G, Huber T.   +7 more
europepmc   +3 more sources

Plasma Proteome-Wide Mendelian Randomization Analysis Reveals Biomarkers and Therapeutic Targets for Different Stages of COVID-19. [PDF]

Transbound Emerg Dis
Background. The COVID‐19 pandemic caused by the SARS‐CoV‐2 virus has resulted in a global health crisis with significant morbidity and mortality. While effective vaccinations have been developed, drug treatments for the disease are still required, particularly for different stages of the disease and to combat evolving variants.
Krishnamoorthy S, Hoo RLC, Cheung CL.
europepmc   +2 more sources

Caractéristiques de femmes vulnérables en lien avec leur participation aux activités d’un centre du Programme canadien de nutrition prénatale à Toronto (Canada)

Promotion de la santé et prévention des maladies chroniques au Canada, 2021
IntroductionLe Programme canadien de nutrition prénatale (PCNP) soutient les organismes communautaires qui fournissent des services de santé maternelle et infantile aux femmes vulnérables sur le plan social et économique. Dans le cadre de notre programme
Jane Francis, Samantha Ismail, Alison Mildon, Stacia Stewart, Bronwyn Underhill, Valerie Tarasuk, Erica Di Ruggiero, Alex Kiss, Daniel W. Sellen, Deborah L. O'Connor   +9 more
doaj   +1 more source