Hydrogen sulfide-induced post-translational modification as a potential drug target
Genes and Diseases, 2023 Hydrogen sulfide (H2S) is one of the three known gas signal transducers, and since its potential physiological role was reported, the literature on H2S has been increasing.
Hao-Jie Chen +6 more
doaj +1 more source
Dynamic rearrangement of nucleoporins during fungal "open" mitosis [PDF]
, 2008 Mitosis in animals starts with the disassembly of the nuclear pore complexes and the breakdown of the nuclear envelope. In contrast to many fungi, the corn smut fungus Ustilago maydis also removes the nuclear envelope.
Theisen, Ulrike +2 more
core +1 more source
Extensive cargo identification reveals distinct biological roles of the 12 importin pathways
eLife, 2017 Vast numbers of proteins are transported into and out of the nuclei by approximately 20 species of importin-β family nucleocytoplasmic transport receptors.
Makoto Kimura +5 more
doaj +1 more source
Translational Oncology, 2023 Background: Hydrogen sulfide (H2S) has been identified as the third gaseous signaling molecule. Endogenous H2S plays a key role in the progression of various types of cancer.
Hong-Gang Wang +13 more
doaj +1 more source
Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria [PDF]
, 1989 A nuclear encoded mitochondrial heat-shock protein hsp60 is required for the assembly into oligomeric complexes of proteins imported into the mitochondrial matrix.
Cheng, Ming Yuan +8 more
core +1 more source
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. [PDF]
, 2020 Deregulated expression of MYC induces a dependence on the NUAK1 kinase, but the molecular mechanisms underlying this dependence have not been fully clarified.
Ade, C.P. +18 more
core +1 more source
The Application of Nanotechnology for the Diagnosis and Treatment of Brain Diseases and Disorders
Frontiers in Bioengineering and Biotechnology, 2021 Brain is by far the most complex organ in the body. It is involved in the regulation of cognitive, behavioral, and emotional activities. The organ is also a target for many diseases and disorders ranging from injuries to cancers and neurodegenerative ...
Ebenezeri Erasto Ngowi +19 more
doaj +1 more source
In Vivo Localization of Fas-Associated Death Domain Protein in the Nucleus and Cytoplasm of Normal Thyroid and Liver Cells [PDF]
, 2009 FADD (Fas-associated death domain) is the main death receptor adaptor molecule that transmits apoptotic signal. Recently, FADD protein was shown to be expressed both in the cytoplasm and nucleus of in vitro cell lines. In contrast to the cytoplasmic FADD,
Chiocchia, Gilles +2 more
core +5 more sources
Taking a holistic view of PEST‐containing nuclear protein (PCNP) in cancer biology
Cancer Medicine, 2019 Polypeptide sequences enriched with proline (P), glutamic acid (E), aspartic acid (D) and serine (S)/ threonine (T) (PEST) have been reported to be the most abundant and frequently distributed at the cellular level.
Attia Afzal +7 more
doaj +1 more source
NcPred for accurate nuclear protein prediction using n-mer statistics with various classification algorithms [PDF]
, 2011 Prediction of nuclear proteins is one of the major challenges in genome annotation. A method, NcPred is described, for predicting nuclear proteins with higher accuracy exploiting n-mer statistics with different classification algorithms namely ...
A. Ganesh +14 more
core +3 more sources