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1990
During interphase, eukaryotic cells are physically separated into a nuclear and a cytoplasmic compartment by a complex organelle, the nuclear envelope. The innermost layer of the nuclear envelope is a polymeric protein network (Fawcett, 1966; Fawcett, 1981) termed the nuclear lamina (NL) (Fig.
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During interphase, eukaryotic cells are physically separated into a nuclear and a cytoplasmic compartment by a complex organelle, the nuclear envelope. The innermost layer of the nuclear envelope is a polymeric protein network (Fawcett, 1966; Fawcett, 1981) termed the nuclear lamina (NL) (Fig.
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Inner nuclear membrane proteins and the nuclear lamina
Journal of Cell Science, 2001The nuclear lamina is a scaffolding structure at the nuclear periphery and is required for maintenance of nuclear shape, spacing of nuclear pore complexes, organization of heterochromatin, DNA replication, and regulation of transcription factors.
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Nuclear lamina and regulation of nuclear envelofe structure
Proceedings, annual meeting, Electron Microscopy Society of America, 1987The nuclear lamina is a protein meshwork that lines the nucleoplasmic surface of the nuclear envelope. In numerous higher eukaryotic cells, the lamina is known to contain a polymer of 1-3 major polypeptides (“lamins“) that form an insoluble supramolecular assembly during interphase.
Frank A. Suprynowicz +3 more
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The Nuclear Lamina and Its Functions in the Nucleus
2003The nuclear lamina is a structure near the inner nuclear membrane and the peripheral chromatin. It is composed of lamins, which are also present in the nuclear interior, and lamin-associated proteins. The increasing number of proteins that interact with lamins and the compound interactions between these proteins and chromatin-associated proteins make ...
Yosef Gruenbaum +8 more
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Relation between nuclear envelope and nuclear lamina in nuclear assemblyin vitro
Science in China Series C: Life Sciences, 1997Xenopus laevis egg extracts cell-free nuclear assembly system was used as an experimental model to study the process of nuclear lamina assembly in nuclear reconstitution in vitro. The experimental results showed that lamin was involved in the nuclear assembly in vitro.
Shutao Cai, Zhonghe Zhai
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Mechanisms and dynamics of nuclear lamina–genome interactions
Current Opinion in Cell Biology, 2014The nuclear lamina (NL) interacts with the genomic DNA and is thought to influence chromosome organization and gene expression. Both DNA sequences and histone modifications are important for NL tethering of the genomic DNA. These interactions are dynamic in individual cells and can change during differentiation and development. Evidence is accumulating
Amendola, Mario, van Steensel, Bas
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On the variation of the major nuclear envelope (lamina) polypeptides
Biochemical and Biophysical Research Communications, 1980Abstract Three polypeptides which predominate in nuclear envelope and nuclear pore complex-lamina fractions are usually identified by their migration rates in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Unfortunately, their migration relative to proteins frequently used as molecular weight standards can vary significantly under ...
Keith R. Shelton +2 more
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Characterization of the Drosophila melanogaster genome at the nuclear lamina
Nature Genetics, 2006The nuclear lamina binds chromatin in vitro and is thought to function in its organization, but genes that interact with it are unknown. Using an in vivo approach, we identified approximately 500 Drosophila melanogaster genes that interact with B-type lamin (Lam).
Bernike Kalverda +5 more
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Functions of the nuclear envelope and lamina in development and disease
Biochemical Society Transactions, 2008Recent findings that some 24 inherited diseases and anomalies are caused by defects in proteins of the NE (nuclear envelope) and lamina have resulted in a fundamental reassessment of the functions of the NE and underlying lamina. Instead of just regarding the NE and lamina as a molecular filtering device, regulating the transfer of macromolecules ...
Lidia Hernandez +2 more
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Encyclopedia of Biological Chemistry III, 2021
B. Paschal, Joshua B. Kelley
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B. Paschal, Joshua B. Kelley
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