Results 111 to 120 of about 13,614,081 (295)

Combinatorial nuclear level density by a Monte Carlo method

, 1993
We present a new combinatorial method for the calculation of the nuclear level density. It is based on a Monte Carlo technique, in order to avoid a direct counting procedure which is generally impracticable for high-A nuclei.
Cerf, Nicolas, Cerf, N.
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The Brink-Axel hypothesis and the

Physics Letters B
Here we report on the measurement of the γ -ray strength function of 128 Te in an inelastic proton scattering experiment. This strength function data were evaluated by three different independent methods: ( γ, γ ′) cross sections, the Oslo Method with ...
P.-A. Söderström, A. Kuşoğlu, D.L. Balabanski, S.-R. Ban, R. Corbu, M. Cuciuc, T. Petruse, A. Spataru, S. Aogaki, R. Borcea, M. Brezeanu, S. Calinescu, C. Costache, A. Dhal, I. Dinescu, N.M. Florea, T. Furuno, A. Gavrilescu, A. Gupta, Y. Honda, N.C. Jerca, T. Kawabata, V. Lelasseux, R. Lica, C. Marin, C. Mihai, S. Niculae, H. Pai, I.P. Pârlea, D.A. Testov, D. Tofan, T. Tozar, A. Turturică, G. Turturică, S. Ujeniuc   +34 more
doaj   +1 more source

Properties of warm nuclei in the quasi-continuum

EPJ Web of Conferences, 2010
Nuclear thermodynamic quantities are extracted from nuclear level densities measured with the CACTUS detector array at the Oslo Cyclotron Laboratory. The experiments are performed with light-particle inelastic or transfer reactions.
Voinov A., Toft H.K., Nyhus H.T., Siem S., Mitchell G.E., Bürger A., Larsen A.C., Algin E., Agvaanluvsan U., Guttormsen M.   +9 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The role of the nuclear level density in spallation neutron studies [PDF]

, 1998
The influence of the nuclear level density parameters of the various nuclides determined recently on the neutron yields, produced by 0.8--1.4 GeV proton bombardments of thick tungsten target, was investigated.
Mughabghab, S. F., Zucker, M. S.
core  

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source