Results 151 to 160 of about 3,441,532 (219)

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

open access: yesThe FEBS Journal, Volume 293, Issue 21, Page 6349-6373, November 2026.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam   +4 more
wiley   +1 more source

EPR spectroscopy 80 years after its discovery. [PDF]

open access: yesSci Adv
Goldfarb D   +5 more
europepmc   +1 more source

Impact of YAQ001 on the Gut Microbiome, Permeability and Markers of Systemic Inflammation in Patients With Cirrhosis

open access: yesLiver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background & Aims YAQ001 is a novel, non‐absorbable, gut‐restricted, multiporous, carbon bead adsorbent. Pre‐clinical studies and a clinical trial suggested its therapeutic potential and safety in patients with cirrhosis. This substudy aimed to explore the effects of YAQ001 on the gut microbiome and their exploratory association with ...
Jinxia Liu   +54 more
wiley   +1 more source

Toroidal Dipole‐Dominated High‐Performance Optical Sensors via Nanoimprinted Tetramer Architectures

open access: yesNanophotonics, Volume 15, Issue 20, 27 October 2026.
We developed a scalable low‐cost nanoimprinted tetramer architecture (NTA) sensor using two‐step nanoimprint lithography. It comprises polystyrene nanopillar tetramer arrays on a PS waveguide and gold mirror, supporting a toroidal‐dipole‐mediated resonant mode at 810 nm with a simulated Q of 3124.
Hongsen Zhao   +8 more
wiley   +1 more source

Characterization of Full‐Length Antibody Complexes Through HDX‐Mass Spectrometry Coupled With NMR Spectroscopy: New Insight Into Avelumab/PD‐L1 Interaction

open access: yesAngewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Combining HDX‐MS and NMR enables the mapping of epitopes and paratopes in full‐length antibody complexes, revealing transient interactions and potential artifacts. ABSTRACT Recombinant biomacromolecules have significantly transformed pharmaceuticals, in particular monoclonal antibodies (mAbs) that target key areas in oncology, immunology, inflammation,
Francesca Sacco   +13 more
wiley   +2 more sources

Impact of Threading State on the Mechanics of γ‐Cyclodextrin–Pyrene Gels

open access: yesAngewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Tuning the threading state of discrete γ‐cyclodextrin (γ‐CD)–pyrene pseudorotaxane crosslinkers controls gel topology and ring mobility. The resulting doubly threaded slide‐ring networks exhibit solvent‐switchable dissipative dynamics, high extensibility, rate‐dependent mechanics, and low hysteresis, revealing how crosslink topology governs macroscopic
Jongwon Oh   +8 more
wiley   +2 more sources

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