Results 131 to 140 of about 49,014 (224)

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, Volume 16, Issue 5, Page 906-920, May 2026.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song   +4 more
wiley   +1 more source

Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

open access: yesDrug Design, Development and Therapy, 2016
Norlaily Mohd Ali,1 M Nadeem Akhtar,2 Huynh Ky,3 Kian Lam Lim,1 Nadiah Abu,4 Seema Zareen,2 Wan Yong Ho,5 Han Kiat Alan-Ong,1 Sheau Wei Tan,6 Noorjahan Banu Alitheen,4 Jamil bin Ismail,2 Swee Keong Yeap,6 Tunku Kamarul7 1Faculty of Medicine and Health ...
Ali NM   +12 more
doaj  

Dengue Virus Capsid Protein Interaction With Nucleic Acids

open access: yesBioFactors, Volume 52, Issue 3, May/June 2026.
Binding of dengue virus capsid protein (DENV C) to ssDNA alters Trp fluorescence intensity, lifetime, and anisotropy, revealing structural rearrangements in the complex and suggesting a possible association with liquid–liquid phase separation (LLPS). ABSTRACT Dengue virus (DENV) transmission has greatly increased in the last decade, partly due to the ...
Nelly M. Silva   +7 more
wiley   +1 more source

Treatment of Parkinson's disease: nanostructured sol–gel silica–dopamine reservoirs for controlled drug release in the central nervous system

open access: yesInternational Journal of Nanomedicine, 2010
Tessy López1–3, José L Bata-García4, Dulce Esquivel5,2, Emma Ortiz-Islas2, Richard Gonzalez3, Jorge Ascencio6, Patricia Quintana7, Gerko Oskam7, Fernando J Álvarez-Cervera4, Francisco J Heredia-L& ...
Tessy López   +3 more
doaj  

Phase Separation of Parkinson's Disease Protein α‐Synuclein: Mechanistic Insights but Biological Uncertainties

open access: yesChemistryEurope, Volume 4, Issue 5, May 2026.
Parkinson's disease‐associated protein α‐synuclein can assemble into liquid condensates under strongly perturbed in vitro and in vivo experimental conditions, including high protein concentration, macromolecular crowding, and when attached to various tags with cross‐linking ability.
Simran Arora   +1 more
wiley   +1 more source

Conjugation‐mediated and polarity‐switchable interfacial layers for fast cycling of lithium‐metal batteries

open access: yesInfoMat, Volume 8, Issue 5, May 2026.
Thiophene‐embedded solid electrolyte interphase exhibits switchable polarity for uniform Li plating, and the electron‐rich cathode electrolyte interphase stabilizes high‐valence Ni ions in the cathode. These molecularly engineered interfacial layers enable fast cycling of lithium‐metal batteries for practical applications.
Jeong‐A. Lee   +14 more
wiley   +1 more source

MAVISp: A modular structure‐based framework for protein variant effects

open access: yesProtein Science, Volume 35, Issue 5, May 2026.
Abstract The role of genomic variants in disease has expanded significantly with the advent of advanced sequencing techniques. The rapid increase in identified genomic variants has led to many variants being classified as Variants of Uncertain Significance or as having conflicting evidence, posing challenges for their interpretation and ...
Matteo Arnaudi   +32 more
wiley   +1 more source

An ALS‐associated mutation in the C‐terminal α‐helix of TDP‐43 uncouples condensate formation and amyloid assembly

open access: yesProtein Science, Volume 35, Issue 5, May 2026.
Abstract TAR DNA‐binding protein 43 (TDP‐43) plays a critical role in RNA metabolism and is incorporated into biomolecular condensates called stress granules. In amyotrophic lateral sclerosis (ALS) and several other neurodegenerative disorders, TDP‐43 undergoes aberrant phase transitions, forming insoluble amyloid aggregates, including fibrils composed
Emily J. Byrd   +4 more
wiley   +1 more source

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