Results 111 to 120 of about 49,014 (224)

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Lipid dysmetabolism in ceruloplasmin‐deficient mice revealed both in vivo and ex vivo by MRI, MRS and NMR analyses

FEBS Open Bio
Ceruloplasmin (Cp) is a ferroxidase that plays a role in cellular iron homeostasis and is mainly expressed in the liver and secreted into the blood. Cp is also produced by adipose tissue, which releases it as an adipokine.
Valeria Mannella, Linda Chaabane, Tamara Canu, Alan Zanardi, Sara Raia, Antonio Conti, Barbara Ferrini, Andrea Caricasole, Giovanna Musco, Massimo Alessio   +9 more
doaj   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

SERS‐Based Nano‐ and Microsystems Toward Biomedical Applications

Small, EarlyView.
This review provides a current overview of nano‐ and microscale SERS‐based devices, encompassing all aspects from material design to practical applications. We highlight controlled SERS‐active architectures, including patterned substrates, nanorods, microspheres, micromotors, and microneedles, as well as combinations of these microfluidic systems.
Gohar Soufi, Tijana Maric, Isidro Badillo‐Ramírez, Juliane Fjelrad Christfort, Matteo Tollemeto, Carmen Milan Guimera, Casper Nisula, Giulia Zappalá, Laura De Vittorio, Marta Rubio‐Huertas, Sungyeong Kim, Ziqiao Li, Morten Bo Søndergaard Svendsen, Zhongyang Zhang, Anja Boisen   +14 more
wiley   +1 more source

Wafer‐Scale Deterministic Fabrication of Axis‐Ratio–Engineered Silicon Nanoparticles for On‐Resonance Electric–Magnetic Dipole Interference

Small, EarlyView.
Wafer‐scale top‐down fabrication yields silicon nanoparticles with exceptional uniformity (CV 1.7%–2.4%), enabling deterministic axis‐ratio tuning. At AR ≈$\approx$ 2.1, electric–magnetic dipoles overlap on‐resonance, producing near‐Kerker forward scattering (F/B ≈$\approx$ 12.5).
Taeyeong Kim, Jungchul Lee
wiley   +1 more source

Case Report: Novel IL10RB variant causing very early onset-inflammatory bowel disease

Frontiers in Immunology
BackgroundVery early onset-inflammatory bowel disease (VEO-IBD) can arise from monogenic defects affecting immune regulation. We report a male child with VEO-IBD caused by a homozygous, loss-of-function IL10RB variant (c.562T>G; p.C188G) that has not ...
Yusuf Usman, Christopher P. Ptak, Christopher P. Ptak, Valeria C. Cohran, Valeria C. Cohran, Brian E. Nolan, Brian E. Nolan, Aisha Ahmed, Aisha Ahmed, Aaruni Khanolkar   +9 more
doaj   +1 more source

Rational Design and Development of Organic Afterglow Nanoparticles for Image‐Guided Interventions

Small Methods, EarlyView.
This review outlines the rational design, synthesis, and standardized characterization of organic afterglow nanoparticles for biomedical imaging and therapy. Mechanistic insights into chemically initiated electron exchange luminescence and reactive oxygen species‐mediated processes are connected to molecular engineering and nanoparticle fabrication ...
Asma Harun, Isabella Vasquez, Hannah Bowman, Robert Posey, Zhongkui Hong, Joshua Tropp, Indrajit Srivastava   +6 more
wiley   +1 more source

Stable Isotopes for the Study of Energy Nutrient Metabolic Pathways in Relation to Health and Disease

Metabolites
Background: Stable isotope-based analytical methods have brought about a significant transformation in the study of energy nutrient metabolism, enabling precise in vivo measurement of metabolic fluxes at systemic, tissue, and organ-specific levels in ...
Dalila Azzout-Marniche, Daniel Tomé
doaj   +1 more source

Tumor cell membrane camouflaged liposomal pharmaceuticals for cascade catalysis‐driven redox modulation and synergistic ROS/RNS antitumor therapy

VIEW, EarlyView.
A tumor cell membrane camouflaged liposomal nanoplatform (C‐MLip@LA) modulates tumor redox homeostasis to enhance targeted therapy. By encapsulating L‐arginine, anchoring MnO2 nanoparticles, and leveraging homologous membrane‐mediated specificity, C‐MLip@LA efficiently triggers a synergistic ROS/RNS cascade, amplifies immunogenic cell death, and ...
Guangrong Zheng, Tengfei Ke, Hongjin Wang, Hong Huang, Ying Zhang, Guanghai Fei, Chengde Liao, Haiyan Yang   +7 more
wiley   +1 more source