Results 101 to 110 of about 19,754 (175)

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 800-828, July/August 2026.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Sequence‐encoded differences in the conformational ensembles of CITED transcriptional activation domains impact coactivator binding

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Recent advances in predicting and modeling conformational ensembles of intrinsically disordered proteins (IDPs) have provided much needed insights into sequence‐ensemble relationships. It is thought that conservation of physicochemical properties, but not the exact identity or order of the amino acids, maintains IDP ensemble properties that ...
To Uyen Do, Emma J. Kraft, Garrett F. Chappell, Stuart Parnham, Rebecca B. Berlow   +4 more
wiley   +1 more source

Guidelines for Comparing Circular Dichroism Spectroscopy and Molecular Dynamics Simulations for Biomolecules

ChemPhysChem, Volume 27, Issue 12, 26 June 2026.
A direct comparison is made between circular dichroism (CD) spectroscopy and molecular dynamics (MD) simulations for studying peptide partitioning through biological membranes. The assumptions and limitations of each method is discussed, and case studies are provided for their use.
Cinzia Campus, Marta Roldo, Charles H. Chen, Roja Hadianamrei, Elisabetta Gavini, Christian Jorgensen   +5 more
wiley   +1 more source

Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

Drug Design, Development and Therapy, 2016
Norlaily Mohd Ali,1 M Nadeem Akhtar,2 Huynh Ky,3 Kian Lam Lim,1 Nadiah Abu,4 Seema Zareen,2 Wan Yong Ho,5 Han Kiat Alan-Ong,1 Sheau Wei Tan,6 Noorjahan Banu Alitheen,4 Jamil bin Ismail,2 Swee Keong Yeap,6 Tunku Kamarul7 1Faculty of Medicine and Health ...
Ali NM, Akhtar MN, Ky H, Lim KL, Abu N, Zareen S, Ho WY, Alan-Ong HK, Tan SW, Alitheen NB, Ismail JB, Yeap SK, Kamarul T   +12 more
doaj  

The Hoechst Dye‐Binding RNA Aptamer Recognizes Its Ligand in a Highly Dynamic Fashion

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
The Hoechst–RNA aptamer binds a tert‐butyl containing derivative of the Hoechst dye. The study presented here shows that the interactions between the RNA and ligand are highly dynamic with the ligand occupying two overlapping binding sites. The interactions are explored using NMR spectroscopy and time‐resolved fluorescence.
Natasha M. Evans, Hunter Little, Thorsten Dieckmann   +2 more
wiley   +1 more source

Treatment of Parkinson's disease: nanostructured sol–gel silica–dopamine reservoirs for controlled drug release in the central nervous system

International Journal of Nanomedicine, 2010
Tessy López1–3, José L Bata-García4, Dulce Esquivel5,2, Emma Ortiz-Islas2, Richard Gonzalez3, Jorge Ascencio6, Patricia Quintana7, Gerko Oskam7, Fernando J Álvarez-Cervera4, Francisco J Heredia-L& ...
Tessy López, José L Bata-García, Dulce Esquivel, et al   +3 more
doaj  

Stereochemical Modulation of Palladacyclopentadienyl Complexes Bearing Diphosphine Ligands: A Key to Enhanced DNA Interaction and Anticancer Activity

European Journal of Inorganic Chemistry, Volume 29, Issue 16, 4 June 2026.
A modular library of structurally robust palladacyclopentadienyl Pd(II) complexes bearing achiral and chiral diphosphines was developed, revealing a strong influence of diphosphine design and ligand chirality on cytotoxicity and selectivity against ovarian cancer cells, including platinum‐resistant models.
Stefania Mautone, Martina Scianna, Isabella Caligiuri, Laura Orian, Pablo Nogara, Nicola Demitri, Flavio Rizzolio, Thomas Scattolin   +7 more
wiley   +1 more source

Special Issue "Application of NMR Spectroscopy in Biomolecules". [PDF]

Int J Mol Sci
Russo L.
europepmc   +1 more source

Quantifying Ligand-to-Protein Distances in Complex Environments Using Intermolecular ¹⁹F PRE NMR Spectroscopy. [PDF]

Chembiochem
Werle Y, Inderfurth ML, Lang CJ, Kovermann M.   +3 more
europepmc   +1 more source

At the core of the interaction: Probing charged side chains in flexible protein regions with simultaneous nuclear magnetic resonance experiments. [PDF]

Protein Sci
Rodella MA, Schiavina M, Mayzel M, Cappanni C, Kümmerle R, Pierattelli R, Felli IC.   +6 more
europepmc   +1 more source