Results 171 to 180 of about 208,246 (250)

Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes

Glia, Volume 74, Issue 2, February 2026.
CD38 deficiency influences brain NAD/NAM metabolism. Global CD38 deficiency drives changes in astrocyte mitochondrial, metabolic, senescence, and neurodegenerative‐related genes. CD38 deficiency alters glial reactivity and astrocyte bioenergetics. ABSTRACT CD38 is an ectoenzyme that converts NAD+ to NAM to help maintain bioenergetic homeostasis.
S. Basak, A. M. Colafrancesco, R. D. Hernandez, X. Wei, L. J. McMeekin, D. Dang, M. Simmons, J. L. Browning, K. Noel, F. Zhou, F. E. Lund, J. S. Saad, S. G. Watsen, A. M. Pickrell, R. M. Cowell, M. L. Olsen   +15 more
wiley   +1 more source

¹H^N, ¹³C, and ¹⁵N resonance assignments of Ca²⁺-calmodulin bound to a BP2 peptide derived from the sheep STRA6 vitamin A transporter (residues 625-656). [PDF]

Biomol NMR Assign
Cook ME, Varney KM, Zhuang X, Yazici AT, Mancia F, Weber DJ.   +5 more
europepmc   +1 more source

Metal‐Coordination Specificity and Structural Dynamics of C. elegans Metallothionein I: Insights From 3D Modeling and MD Simulations

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 620-632, February 2026.
ABSTRACT Metallothioneins (MTLs) are small, cysteine‐rich proteins known for their ability to bind metal ions and exhibit flexible, disordered structures. The structural and functional characteristics of metallothionein I (MTL‐1) from Caenorhabditis elegans were investigated, focusing on its behavior in both metal free (MTL‐1 Apo) and metal‐bond states
Nilvea Ramalho de Oliveira, Andrei Santos Siqueira, Paulo Sérgio Alves Bueno, Evonnildo Costa Gonçalves, Juliano Zanette   +4 more
wiley   +1 more source

Nuclear Magnetic Resonance-based fragment screen of the E3 ligase Fem-1 homolog B. [PDF]

Protein Sci
Katinas JM, Amporndanai K, Taylor AJ, Rose KL, Gareiss PC, Crespo RA, Phan J, Waterson AG, Fesik SW.   +8 more
europepmc   +1 more source

Compost Tea as a Natural Bioactive Solution: Unlocking the Antimicrobial and Antiviral Potential of Bell Pepper and Citrus Wastes

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
Compost teas derived from bell pepper and citrus waste are rich in bioactive phenolics and lignin derivatives, showing strong antibacterial activity against gram‐positive bacteria and potent antiviral effects against HSV‐1 and RSV. These findings highlight their potential as sustainable, circular bioresources for biomedical applications.
Maria Vittoria Verrillo, Roberta Della Marca, Vincenza Cozzolino, Annalisa Chianese, Carla Zannella, Massimiliano Galdiero, Riccardo Spaccini, Anna De Filippis   +7 more
wiley   +1 more source

Structural and functional dissection of the WH2/DAD motif of INF2, a formin linked to human inherited degenerative disorders

The FEBS Journal, Volume 293, Issue 3, Page 825-841, February 2026.
The INF2 WH2/DAD domain, composed of hydrophobic and basic regions, forms a single α‐helix in solution. The hydrophobic segment is essential for INF2 function, as its deletion disrupts actin dynamics and causes nuclear abnormalities, like those seen in pathogenic INF2 DID variants. In contrast, natural INF2 WH2/DAD variants found in patients with renal
Leticia Labat‐de‐Hoz, Laura Fernández‐Martín, Paula Morales, Isabel Correas, María Ángeles Jiménez, Miguel Angel Alonso   +5 more
wiley   +1 more source

Quantum Life Science: A Paradigm for Life Science Research. [PDF]

ACS Nano
Kono H, Yukawa H, Hiromoto T, Igarashi R, Takakusagi Y, Adachi M, Baba Y.   +6 more
europepmc   +1 more source

Raising microwave power drives solid effect DNP enhancements beyond 500 at 9.4 T. [PDF]

Magn Reson Lett
Shi H, Bao Q, Zhou X, Liu M, Liu C.
europepmc   +1 more source

Combining Fluorescence and Magnetic Resonance Imaging in Drug Discovery-A Review. [PDF]

Pharmaceuticals (Basel)
Smolak B, Dynarowicz K, Bartusik-Aebisher D, Henrykowska G, Aebisher D, Guz W.   +5 more
europepmc   +1 more source

Solid trouble: tau and TDP-43 interaction in aggregation and pathology. [PDF]

EMBO J
Fawzi NL.
europepmc   +1 more source