Results 71 to 80 of about 3,441,532 (219)

Preserving Proton Resolution Under Cryogenic Dynamic Nuclear Polarization for Biomolecular Solid‐State NMR

Angewandte Chemie, EarlyView.
High‐resolution proton detection is preserved under cryogenic dynamic nuclear polarization (DNP) by combining fast MAS, extensive deuteration and selective methyl protonation. This strategy enables proton‐detected structural studies of biomolecular solids with enhanced sensitivity under DNP conditions.
James Tolchard, Tanguy Le Marchand, Nadia El Mammeri, Kshama Sharma, Ajit Kumar Bishoyi, Mélanie Berbon, Kristaps Jaudzems, Dorothea Wisser, Asen Daskalov, Sven J. Saupe, Jan Stanek, Zhiyu Sun, Olivier Ouari, Birgit Habenstein, Anne Lesage, Guido Pintacuda, Antoine Loquet   +16 more
wiley   +2 more sources

Spin-locking in low-frequency reaction yield detected magnetic resonance [PDF]

, 2013
The purported effects of weak magnetic fields on various biological systems from animal magnetoreception to human health have generated widespread interest and sparked much controversy in the past decade.
Wedge, Christopher, Ferguson, Kelly-Anne, Norman, Stuart A., Lau, Jason C. S., Wedge, Christopher J., Hore, P. J., Timmel, Christiane R., Timmel, C. R. (Christiane R.)   +7 more
core   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Time‐Resolved Multidimensional NMR Spectroscopy Reveals the Bifurcated Folding Pathway of a Thrombin‐Binding DNA G4–Azobenzene Derivative Complex

Angewandte Chemie, EarlyView.
A photoswitchable ligand was used to trigger conformational changes within the thrombin binding aptamer DNA G‐Quadruplex. These reversible ligand driven rearrangements were examined by time‐resolved NMR experiments to gain insight of the dynamic folding landscape of the G‐quadruplex.
Jason Martins, Julia Wirmer‐Bartoschek, Harald Schwalbe   +2 more
wiley   +2 more sources

Nuclear magnetic resonance spectroscopy and computational methods for the characterization of materials in solution and the solid state [PDF]

, 2010
Nuclear Magnetic Resonance (NMR) and computational methods increasingly play a predominant and indispensable role in modern chemical research. The insights into the local nuclear environment that NMR can provide is unique information which allows the ...
Carnevale, Diego
core   +2 more sources

Efficient Experimental Design for Measuring Magnetic Susceptibility of Arbitrarily Shaped Materials by MRI [PDF]

, 2018
This work was funded by the Institute for Basic Science, under grant IBS-R015-D1. The SQUID measurement was provided by Dr. Seung-young Park from Korea Basic Science Institute (KBSI).
Seon-ha Hwang, Seung-Kyun Lee
core   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Biomolecular EPR Meets NMR at High Magnetic Fields

Magnetochemistry, 2018
In this review on advanced biomolecular EPR spectroscopy, which addresses both the EPR and NMR communities, considerable emphasis is put on delineating the complementarity of NMR and EPR regarding the measurement of interactions and dynamics of large ...
Klaus Möbius, Wolfgang Lubitz, Nicholas Cox, Anton Savitsky   +3 more
doaj   +1 more source

A Fluorogenic Cysteine‐Tetrapeptide Tagging Strategy for Nonperturbative Protein Labeling and Protein–Ligand Interaction Tracking

Advanced Science, EarlyView.
A compact Phe‐Cys‐Pro‐Phe (FCPF) tag and an environment‐sensitive SBD‐Cl‐derived probe form a sequence‐selective fluorogenic pair for wash‐free live‐cell protein imaging. This minimally perturbing chemistry allows flexible insertion at termini or loops, produces strong fluorescence upon local microenvironment confinement, supports FRET‐assisted ...
Xiao Wang, Xingcan Pan, Yongling Ying, Ziqian Bai, Jingming Zhang, Zhuang Shao, Jialiang Qian, Hongwei Li, Ning Zhang, Fan Yang, Yuan Liu, Xing Yang   +11 more
wiley   +1 more source

Surface‐State‐Driven Selectivity of Electrocatalytic Glucose Oxidation: Metallic Au, Au─OH, and CuO

Advanced Science, EarlyView.
In the electrochemical oxidation of glucose, whether the pyranose ring opens upon adsorption decides the reaction pathway: ring opening on metallic Au yields gluconic acid, gluconolactone formation on Au─OH leads to glucaric acid, and C─C cleavage on CuO gives formic acid. Surface state thus governs product selectivity.
Myeonghwan Oh, Hoeun Seong, Ga Eun Jo, Jiyoung Hwang, Yurim Sohn, Kyoungsuk Jin, Jong Hyeok Park, Wooyul Kim, Seok Ki Kim, Dong Ki Lee   +9 more
wiley   +1 more source