Results 51 to 60 of about 3,624,314 (247)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Paired-pulse TMS of premotor cortex produces non-linear suppressive effects on neural activity in the targeted network - a TMS-fMRI study

NeuroImage
Background: Transcranial magnetic stimulation (TMS) activates neural circuits in targeted and connected areas, yet it remains unclear how “TMS-dose” relates to local or network responses, particularly outside the primary motor hand area.
Laerke Gebser Krohne, Sofus Nygaard, Maud Eline Ottenheijm, Marie Louise Liu, Axel Thielscher, Hartwig Roman Siebner, Kristoffer Hougaard Madsen   +6 more
doaj   +1 more source

AN OVERVIEW OF NUCLEAR MAGNETIC RESONANCE [PDF]

, 2013
There are a number of techniques available for investigating the structures of materials. One of the most powerful techniques capable of providing information both about the structure of materials and about the dynamics of process within those materials ...
Nicolas Gunawidjaja, Philips, Gunawidjaja, P. N. (Philips)   +1 more
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Assessment of a diffusion phantom for quality assurance in brain microstructure diffusion MRI studies

Scientific Reports
Diffusion-weighted imaging (DWI) is a key contrast mechanism in MRI which allows for the assessment of microstructural properties of brain tissues by measuring the displacement of water molecules.
Mattia Ricchi, Aaron Axford, Jordan McGing, Ayaka Shinozaki, Kylie Yeung, Rebecca Mills, Fulvio Zaccagna, Damian J. Tyler, Claudia Testa, James T. Grist   +9 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

DNA Binding Mechanism of The Virulence Regulator SarA in Staphylococcus aureus

Journal of Magnetic Resonance Open
Staphylococcus aureus infections have long been a significant challenge to public health, particularly due to the emergence of multiple drug-resistant strains. SarA is a critical global regulator in S.
Dihong Fu, Xiaoyun Guo, Bo Duan, Bin Xia
doaj   +1 more source

Spin-locking in low-frequency reaction yield detected magnetic resonance [PDF]

, 2013
The purported effects of weak magnetic fields on various biological systems from animal magnetoreception to human health have generated widespread interest and sparked much controversy in the past decade.
Wedge, Christopher, Ferguson, Kelly-Anne, Norman, Stuart A., Lau, Jason C. S., Wedge, Christopher J., Hore, P. J., Timmel, Christiane R., Timmel, C. R. (Christiane R.)   +7 more
core   +1 more source