Results 81 to 90 of about 3,105,483 (336)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Plans for Hadronic Structure Studies at J-PARC

, 2010
Hadron-physics projects at J-PARC are explained. The J-PARC is the most-intense hadron-beam facility in the multi-GeV high-energy region. By using secondary beams of kaons, pions, and others as well as the primary-beam proton, various hadron projects are
, , , , , , , Ajimura S, Akaishi Y, Alekseev M G (COMPASS Collaboration), Bai M, Beer G, Chiba J, D'Alesio U, Hayano R S, Higinbotham D, Hino S, Hotta T, Kumano S, Muto R, Nagamiya S, S Kumano, Strikman M, Yokoya H   +23 more
core   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Educational physical experiment as a research tool in the cloud-oriented learning environment

CTE Workshop Proceedings, 2017
Research goals: study the feasibility of the research students with educational physical experiment in the cloud-oriented learning environment. Research objectives: the role of research students in the cloud-oriented learning environment through ...
M. V. Khomutenko
doaj   +1 more source

Nuclear Security Applications of Antineutrino Detectors: Current Capabilities and Future Prospects

, 2009
Antineutrinos are electrically neutral, nearly massless fundamental particles produced in large numbers in the cores of nuclear reactors and in nuclear explosions.
Baldwin, G., Bernstein, A., Boyer, B., Goodman, M., Learned, J., Lund, J., Reyna, D., Svoboda, R.   +7 more
core   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Hyperneutron Stars from an Ab Initio Calculation

The Astrophysical Journal
The equation of state (EOS) of neutron matter plays a decisive role in understanding the neutron star properties and the gravitational waves from neutron star mergers. At sufficient densities, the appearance of hyperons generally softens the EOS, leading
Hui Tong, Serdar Elhatisari, Ulf-G. Meißner​   +2 more
doaj   +1 more source

The extreme light infrastructure—nuclear physics (ELI-NP) facility: new horizons in physics with 10 PW ultra-intense lasers and 20 MeV brilliant gamma beams

Reports on progress in physics. Physical Society, 2018
The European Strategy Forum on Research Infrastructures (ESFRI) has selected in 2006 a proposal based on ultra-intense laser fields with intensities reaching up to 1022–1023 W cm−2 called ‘ELI’ for Extreme Light Infrastructure.
S. Gales, K. A. Tanaka, D. Balabanski, F. Negoita, D. Stutman, O. Tesileanu, C. A. Ur, D. Ursescu, I. Andrei, Stefan Ataman, M. Cernaianu, L. D'Alessi, I. Dăncuş, B. Diaconescu, Nikolay Djourelov, D. Filipescu, P. Ghenuche, D. Ghita, C. Matei, K. Seto, Ming Zeng, N. Zamfir   +21 more
semanticscholar   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source