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Annual Review of Biochemistry, 1995
The nuclear pore complex (NPC) creates an aqueous channel across the nuclear envelope through which macromolecular transport between nucleus and cytoplasm occurs. Nucleocytoplasmic traffic is bidirectional and involves diverse substrates, including protein and RNA.
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The nuclear pore complex (NPC) creates an aqueous channel across the nuclear envelope through which macromolecular transport between nucleus and cytoplasm occurs. Nucleocytoplasmic traffic is bidirectional and involves diverse substrates, including protein and RNA.
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The Structure of the Nuclear Pore Complex
Annual Review of Biochemistry, 2011In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and translation in the cytoplasm imposes the requirement of transporting thousands of macromolecules between these two compartments. Nuclear pore complexes (NPCs) are the sole gateways that facilitate this macromolecular exchange across the nuclear envelope ...
Hoelz, André +2 more
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Cancer and the Nuclear Pore Complex
2014The nuclear pore complex (NPC) mediates trafficking between the cytoplasm and nucleoplasm. It also plays key roles in other nuclear processes such as chromatin silencing, transcriptional regulation, and DNA damage repair. Nucleoporins, the structural components of the NPC, have been linked to a multitude of cancers through chromosomal translocations ...
Dan N. Simon, Michael P. Rout
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Pores for thought: nuclear pore complex proteins
Trends in Cell Biology, 1994Nuclear pore complexes (NPCs) are enormous macromolecular structures that mediate the active exchange of proteins and RNPs between the nucleus and cytoplasm. Recent work has resulted in a windfall of identified NPC polypeptides, many with unique sequences.
Michael P. Rout, Susan R. Wente
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2010
Nuclear pore complexes (NPCs) are large macromolecular assemblies with an estimated mass of about 125 million Dalton. Depending on the activity of a cell, the number of NPCs varies but is usually around 3000–4000 per nucleus. NPCs are sites of bidirectional transport.
Jürgen Roth, Margit Pavelka
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Nuclear pore complexes (NPCs) are large macromolecular assemblies with an estimated mass of about 125 million Dalton. Depending on the activity of a cell, the number of NPCs varies but is usually around 3000–4000 per nucleus. NPCs are sites of bidirectional transport.
Jürgen Roth, Margit Pavelka
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1996
The nuclear envelope forms the boundary between the nucleus and the cytoplasm and as such regulates the exchange of macromolecules between the two compartments. The channels through the nuclear envelop that actually mediate this macromolecular traffic are the nuclear pore complexes.
Brain Burke +2 more
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The nuclear envelope forms the boundary between the nucleus and the cytoplasm and as such regulates the exchange of macromolecules between the two compartments. The channels through the nuclear envelop that actually mediate this macromolecular traffic are the nuclear pore complexes.
Brain Burke +2 more
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Functional Architecture of the Nuclear Pore Complex
Annual Review of Biophysics, 2012The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm. NPCs fuse the inner and outer nuclear membranes to form aqueous translocation channels that allow the free diffusion of small molecules and ions, as well as receptor-mediated transport of large macromolecules.
Grossman, Einat +2 more
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Nuclear calcium and the regulation of the nuclear pore complex
BioEssays, 1997AbstractIn eukaryotic cells the nucleus and its contents are separated from the cytoplasm by the nuclear envelope. Macromolecules, as well as smaller molecules and ions, can cross the nuclear envelope through the nuclear pore complex. Molecules greater than approx.
Carmen Perez-Terzic +3 more
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The molecular architecture of the nuclear pore complex
Nature, 2007Nuclear pore complexes (NPCs) are proteinaceous assemblies of approximately 50 MDa that selectively transport cargoes across the nuclear envelope. To determine the molecular architecture of the yeast NPC, we collected a diverse set of biophysical and proteomic data, and developed a method for using these data to localize the NPC's 456 constituent ...
Svetlana Dokudovskaya +12 more
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Structure and Function of the Nuclear Pore Complex
Annual Review of Cell and Developmental Biology, 1992INTRODUCTION 495 NUCLEAR TRANSPORT 496 An Overview 496 Structure of the Nuclear Pore Complex 498 Protein Import 500 Protein Export 508 RNA Export 509 RNA Import . . . . . . . . . . . . . . . . . . . . . . . .. ... . . . . . . .... .. .. 510 Genetic Approaches to RNA and Protein Transport 511 Control of Nuclear Transport ......... .......
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