Results 91 to 100 of about 2,139,515 (306)

The use of radiocobalt as a label improves imaging of EGFR using DOTA-conjugated Affibody molecule

Scientific Reports, 2017
Several anti-cancer therapies target the epidermal growth factor receptor (EGFR). Radionuclide imaging of EGFR expression in tumours may aid in selection of optimal cancer therapy.
Javad Garousi, Ken G. Andersson, Johan H. Dam, Birgitte B. Olsen, Bogdan Mitran, Anna Orlova, Jos Buijs, Stefan Ståhl, John Löfblom, Helge Thisgaard, Vladimir Tolmachev   +10 more
doaj   +1 more source

Comparison of Nuclear Matrix Protein-22 and Urine Cytology in Diagnosing Bladder Cancer [PDF]

, 2018
Background: Urine cytology (UC) is a classic marker used to detect bladder Malignancy through urine examination microscopically at the presence of Malignant transitional cells that are released.
Soedarso, M. A. (Mohamad), Tjahjati, M. I. (Maria), Wahyuni, Y. (YinYin)   +2 more
core  

Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. [PDF]

, 2012
Vascular cell adhesion molecule-1 (VCAM-1) plays important roles in development and inflammation. Tumor necrosis factor-α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin-matrix signaling, respectively.
Chen, Xiao Lei, Cheresh, David A, Lawson, Christine, Lim, Ssang-Taek, Miller, Nichol LG, Schlaepfer, David D, Tancioni, Isabelle, Uryu, Sean, Walsh, Colin T, Weis, Sara M   +9 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Role of 3-mercaptopyruvate sulfurtransferase in cancer: Molecular mechanisms and therapeutic perspectives

Translational Oncology
The occurrence and development of tumor is mediated by a wide range of complex mechanisms. Subsequent to nitric oxide and carbon monoxide, hydrogen sulfide (H2S) holds the distinction of being the third identified gasotransmitter.
Ka Zhang, Yi-Wen Zhu, Ao-Qi Tang, Ze-Tao Zhou, Yi-Lun Yang, Zi-Hui Liu, Yan Li, Xiao-Yi Liang, Zhi-Fen Feng, Jun Wang, Tong Jiang, Qi-Ying Jiang, Dong-Dong Wu   +12 more
doaj   +1 more source

Nuclear Resonance Vibrational Spectroscopy of Iron Sulfur Proteins

, 2012
Nuclear inelastic scattering in conjunction with density functional theory (DFT) calculations has been applied for the identification of vibrational modes of the high-spin ferric and the high-spin ferrous iron-sulfur center of a rubredoxin-type protein ...
A. I. Chumakov, A. X. Trautwein, A.J.H. Wachters, B. Miehlich, C. Lee, C. Schmidt, H. Paulsen, H. Winkler, M.J. Frisch, P. Wegner, P. Wegner, P.J. Hay, R. Rüffer, R.S. Czernuszewicz, T.G. Spiro, T.R. Cundari, U. Bergmann, V. Schünemann, V. Schünemann, W.J. Stevens   +19 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hepatitis C virus NS5A targets the nucleosome assembly protein NAP1L1 to control the innate cellular response [PDF]

, 2017
Hepatitis C virus (HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular ...
Cesarec, Mia, Da Silva Filipe, Ana, Licastro, Danilo, Marcello, Alessandro, McLauchlan, John, Çevik, Recep Emrah   +5 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Achieving the Way for Automated Segmentation of Nuclei in Cancer Tissue Images through Morphology-Based Approach: a Quantitative Evaluation [PDF]

, 2010
In this paper we address the problem of nuclear segmentation in cancer tissue images, that is critical for specific protein activity quantification and for cancer diagnosis and therapy.
A. Acquaviva, Bresson, Caselles, Chan, Chang, Chen, Chen, Di Cataldo, Di Cataldo, Diaz, E. Ficarra, E. Macii, Elmoataz, Ficarra, Garrido, Hengerer, Huang, Jacob, Jacob, Jrgensena, Kass, Lejeune, Leventon, Li, Ling Pi, McCullough, McInerney, Milstei, Mukherjee, Nattkemper, Osher, Paragios, Ridler, Roerdink, Rousson, Ruifrok, Ruifrok, S. Di Cataldo, Taneja, Tukey, Xu, Yang, Zhu   +42 more
core   +1 more source