Results 241 to 250 of about 8,215,941 (358)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Nitrogen mustard induces dynamic nuclear protein spectrum change and DNA-protein crosslinking, with p97 mediating repair. [PDF]

Heliyon
Cheng J, Liu H, Yu W, Dong X, Sai Y, Ye F, Dan G, Chen M, Zhao Y, Zhang X, Zou Z.   +10 more
europepmc   +1 more source

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

Science, 2013
J. Swift, I. Ivanovska, A. Buxboim, T. Harada, P. Dingal, Joel Pinter, J. D. Pajerowski, K. Spinler, Jae-Won Shin, M. Tewari, F. Rehfeldt, D. Speicher, D. Discher, D. Discher   +13 more
semanticscholar   +1 more source

Signal-mediated nuclear export pathways of proteins and RNAs

, 1996
Utz Fischer, W. Matthew Michael, Reinhard Lu ̈hrmann, Gideon Dreyfuss   +3 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Arabidopsis transcription factor ANAC102 predominantly expresses a nuclear protein and acts as a negative regulator of methyl viologen-induced oxidative stress responses. [PDF]

J Exp Bot
Luo X, Jiang X, Schmitt V, Kulkarni SR, Tran HC, Kacprzak SM, Van Breusegem F, Van Aken O, Vandepoele K, De Clercq I.   +9 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

A new light on the UFO mystery: Zmufo1 encodes a nuclear protein that modulates redox levels and epigenetic status during basal endosperm differentiation in maize. [PDF]

Plant Cell
Doll NM.
europepmc   +1 more source

Faculty Opinions recommendation of Nuclear localizations of the herpes simplex virus type 1 tegument proteins VP13/14, vhs, and VP16 precede VP22-dependent microtubule reorganization and VP22 nuclear import.

, 2005
Rozanne M. Sandri-Goldin
openalex   +2 more sources

Analysis of insect nuclear small heat shock proteins and interacting proteins

, 2020
Mohamed Taha Moutaoufik, Robert M. Tanguay   +1 more
openalex   +2 more sources