Results 101 to 110 of about 846,262 (295)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Alpha-particle clustering in excited expanding self-conjugate nuclei

, 2016
The fragmentation of quasi-projectiles from the nuclear reaction 40Ca + 12C at 25 MeV/nucleon was used to produce alpha-emission sources. From a careful selection of these sources provided by a complete detection and from comparisons with models of ...
Ademard, G., Borderie, B., Cardella, G., De Filippo, E., Geraci, E., Lanzalone, G., Lombardo, I., Lopez, O., Maiolino, C., Neindre, N. Le, Pagano, A., Pirrone, S., Politi, G., Raduta, Ad. R., Rivet, M. F., Rizzo, F., Russotto, P.   +16 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Photonuclear reactions in astrophysical p-process: Theoretical calculations and experiment simulation based on ELI-NP

EPJ Web of Conferences, 2017
The astrophysical p-process is an important way of nucleosynthesis to produce the stable and proton-rich nuclei beyond Fe which can not be reached by the s- and r-processes. In the present study, the astrophysical reaction rates of (γ,n), (γ,p), and (γ,α)
Xu Yi, Luo Wen, Balabanski Dimiter, Goriely Stephane, Matei Catalin, Tesileanu Ovidiu   +5 more
doaj   +1 more source

Accretion rate and the occurrence of multi-peaked X-ray bursts

, 2007
Most Type I X-ray bursts from accreting neutron stars have a lightcurve with a single peak, but there is a rare population of faint bursts that are double or even triple peaked.
A. L. Watts, Bhattacharyya, Bhattacharyya, Cooper, Cooper, Cornelisse, Fisker, Fujimoto, Fujimoto, Fushiki, Galloway, Hasinger, I. Maurer, Inogamov, Jonker, Kuulkers, Lewin, Narayan, Paczynski, Penninx, Prins, Spitkovsky, Strohmayer, Sztajno, van der Klis, van Paradijs   +25 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The modeling of the reaction cross sections in the production of teranositic radionuclides

Nucleus, 2019
We utilize various nuclear reaction codes with the aim to guide, interpret, and support the experiments in the proton-induced production measurements of radionuclides for the development of innovative radio-pharmaceuticals.
Andrea Fontana, Gaia Pupillo, Liliana Mou, Carlos Rossi Alvarez, Juan Esposito, Luciano Canton   +5 more
doaj  

Calculation of photo-nuclear reaction cross sections for 16O

EPJ Web of Conferences, 2015
Because of the high thermal expansion coefficient of uranium, the fuel used in nuclear power plants is usually in the form of UO2 which has ceramic structure and small thermal expansion coefficient.
Arasoglu Ali, Ozdemir Omer Faruk
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source