Unlocking the potential of cell‐permeable nanobodies for intracellular applications
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Transitions To Door-way States And Nuclear Responses Against 2-body External Fields [PDF]
Nuclear microscopic structural models that treat two-body effective interactions self-consistently becomes available, one of which is second-random-phase-approximation (SRPA).
Minato Futoshi
doaj +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Cross-section Calculations of 175Lu(n,p)175Yb reaction for production of medically important radioisotope 175Yb [PDF]
Ytterbium-175 (175Yb) is considered suitable for the preparation of therapeutic radiopharmaceuticals due to its decay characteristics (T1/2 = 4.18 d).
Nadeem Muhammad +4 more
doaj +1 more source
Nuclear astrophysics is a rapidly developing interdisciplinary field of research that has received extensive attention from the scientific community since the mid-twentieth century.
Wei-ping Liu +30 more
semanticscholar +1 more source
STARLIB: A NEXT-GENERATION REACTION-RATE LIBRARY FOR NUCLEAR ASTROPHYSICS [PDF]
STARLIB is a next-generation, all-purpose nuclear reaction-rate library. For the first time, this library provides the rate probability density at all temperature grid points for convenient implementation in models of stellar phenomena.
A. Sallaska +5 more
semanticscholar +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Nuclear Reaction Data Centers [PDF]
The cooperating Nuclear Reaction Data Centers are involved in the compilation and exchange of nuclear reaction data for incident neutrons, charged particles and photons.
McLane, V. +3 more
core
Nuclear Models in FLUKA: Present Capabilities, Open Problems, and Future Improvements
The nuclear reaction models embedded in the FLUKA code cover hadron, ion, photon and neutrino induced nuclear interactions from energies as low as few tens of MeV up to several tens of TeV. A short description of the main physics ingredients in the FLUKA
A. Fassò +27 more
core +1 more source

