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Structural studies on nuclear receptors
Cellular and Molecular Life Sciences, 2000Nuclear receptors are DNA-binding factors which regulate the transcription of sets of specific genes in response to cognate ligands, usually small lipophilic molecules, thus controlling numerous physiological events in development, procreation, homeostasis, and cellular life.
Renaud, Jean-Paul, Moras, Dino
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2000
The nuclear receptor superfamily consists of a class of transcription factors comprising more than 100 different proteins. In contrast to membrane-bound receptors, the nuclear receptors are intracellular and act by controlling the activity of genes directly. Most members of this family bind directly to small lipidsoluble signaling molecules, or ligands,
Deepak S. Lala, Richard A. Heyman
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The nuclear receptor superfamily consists of a class of transcription factors comprising more than 100 different proteins. In contrast to membrane-bound receptors, the nuclear receptors are intracellular and act by controlling the activity of genes directly. Most members of this family bind directly to small lipidsoluble signaling molecules, or ligands,
Deepak S. Lala, Richard A. Heyman
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The Drosophila nuclear receptors: new insight into the actions of nuclear receptors in development
Current Biology, 1992In Drosophila melanogaster, an increasing number of members of the steroid hormone receptor superfamily are being identified and characterized. Molecular and genetic analysis of receptor function provides evidence for a set of functions underlying the determination of pattern formation, metamorphosis, eye development, and reproduction.
Ronald M. Evans +2 more
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Nuclear Receptors and the Control of Metabolism
Annual Review of Physiology, 2003▪ Abstract The metabolic nuclear receptors act as metabolic and toxicological sensors, enabling the organism to quickly adapt to environmental changes by inducing the appropriate metabolic genes and pathways. Ligands for these metabolic receptors are compounds from dietary origin, intermediates in metabolic pathways, drugs, or other environmental ...
Johan Auwerx +3 more
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2009
Publisher Summary The first steroid hormone to be isolated, purified, and characterized was the estrous-inducing substance, estrin (C18H22O2) obtained in gram quantities from the urine of pregnant women. The steroid and thyroid hormones, and other lipophilic messengers are carried by specific binding proteins in the circulation.
Bastien D. Gomperts +2 more
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Publisher Summary The first steroid hormone to be isolated, purified, and characterized was the estrous-inducing substance, estrin (C18H22O2) obtained in gram quantities from the urine of pregnant women. The steroid and thyroid hormones, and other lipophilic messengers are carried by specific binding proteins in the circulation.
Bastien D. Gomperts +2 more
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-vornhagen +2 more
exaly
2016
Of all the hormones, sex steroids have the longest history of fierce public interest dating back to the origins of our great affair with domestic animals. Steroids bind intracellular receptors, a large family of proteins with diverse ligands and named nuclear receptors.
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Of all the hormones, sex steroids have the longest history of fierce public interest dating back to the origins of our great affair with domestic animals. Steroids bind intracellular receptors, a large family of proteins with diverse ligands and named nuclear receptors.
openaire +2 more sources
Current treatment and recent progress in gastric cancer
Ca-A Cancer Journal for Clinicians, 2021Smita S Joshi, Brian D Badgwell
exaly