Results 341 to 350 of about 5,069,870 (397)

Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation

Nature Reviews Endocrinology, 2020
K. De Bosscher, Sofie J. Desmet, Dorien Clarisse, E. Estébanez-Perpiñá, L. Brunsveld   +4 more
semanticscholar   +1 more source

Identification of a nuclear receptor for bile acids.

Science, 1999
M. Makishima, Arthur Y. Okamoto, J. Repa, H. Tu, R. Learned, Alvin Luk, Mitchell V. Hull, K. Lustig, D. Mangelsdorf, B. Shan   +9 more
semanticscholar   +1 more source

Nuclear Receptors and Bone

Annals of the New York Academy of Sciences, 2007
Abstract:  Nuclear receptors (NRs) represent a class of ligand‐dependent and ‐independent transcription factors with importance to the regulation of development, reproduction, and metabolism. The emergence of new understanding of the structure, function, and role in disease of NRs provides new insights into the interaction between genetics and the ...
openaire   +2 more sources

Bile acids: natural ligands for an orphan nuclear receptor.

Science, 1999
D. Parks, S. Blanchard, R. Bledsoe, Gyan Chandra, T. Consler, S. Kliewer, J. Stimmel, T. Willson, A. Zavacki, D. Moore, J. Lehmann   +10 more
semanticscholar   +1 more source

Signalling through nuclear receptors

Nature Reviews Molecular Cell Biology, 2002
A century ago, secretions from the pancreas were described as 'hormones', which we now know are secreted from all ductless glands. The development of various technologies has already contributed a great deal -- and will undoubtedly offer more -- to our understanding of their mode of action.
openaire   +2 more sources

Nuclear receptor drug discovery

Current Opinion in Chemical Biology, 2008
Nuclear receptors (NR) are ligand-activated transcription factors that regulate the activation of a variety of important target genes. There are 48 genes that encode NRs in the human genome, and these receptors now represent one of the most important targets for therapeutic drug development.
openaire   +2 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023

exaly  

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Boris Böll, Victoria Metaxa   +2 more
exaly  

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

Nature, 1995
A. Hörlein, A. Näär, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Yasutomi Kamei, M. Söderström, C. Glass, M. Rosenfeld   +10 more
semanticscholar   +1 more source