Results 201 to 210 of about 6,710,080 (339)

Orphan nuclear receptors recruit TRIM28 to promote telomeric H3K9me3 for the ALT pathway. [PDF]

EMBO J
Tsai CT, Gaela VM, Hsia HY, Huang YC, Shen YL, Chen LY.   +5 more
europepmc   +1 more source

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.

Molecules and Cells, 2000
Timothy T. Lu, M. Makishima, J. Repa, K. Schoonjans, T. A. Kerr, J. Auwerx, D. Mangelsdorf   +6 more
semanticscholar   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Nuclear receptors as therapeutic targets in metabolic and cardiovascular disorders. [PDF]

iScience
Li F, Chen Q, Dai Y, Lu L.
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Repurposing nuclear receptors for ligand-responsive liquid condensate formation and gene regulation. [PDF]

Nat Commun
Rihtar E, Fink T, Ivanovski F, Koplan E, Jerala R.   +4 more
europepmc   +1 more source

NUCLEAR RECEPTORS [PDF]

British Journal of Pharmacology, 2009
openaire   +3 more sources

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Orphan Nuclear Receptors expression and function in breast cancer cells: oncogenic action of the NR2F6 receptor. [PDF]

Cell Commun Signal
Caricasulo MA, Paroni G, Zanetti A, Brunelli L, Kurosaki M, Cavallaro AV, Foglia M, Remoli G, Guarrera L, Bolis M, Terao M, Garattini E.   +11 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source