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Bioinformatics of Nuclear Receptors
2003Publisher Summary This chapter reviews the information that biologists interested in nuclear receptors can get by using a computer, including general resources and those specialized in nuclear receptors, whether for accessing data or analyzing it.
Marc, Robinson-Rechavi, Vincent, Laudet
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Ubiquitination of nuclear receptors
Clinical Science, 2017Nuclear receptors (NRs) are cellular proteins, which upon ligand activation, act to exert regulatory control over transcription and subsequent expression. Organized via systemic classification into seven subfamilies, NRs partake in modulating a vast expanse of physiological functions essential for maintenance of life.
Jimmy, El Hokayem +3 more
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Nuclear receptors: recent drug discovery for cancer therapies.
Endocrine reviews, 2019Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human physiology and pathology, serving as sensors of stimuli, master regulators of downstream molecular events and hubs governing complex gene regulatory networks ...
Linjie Zhao +2 more
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Annual Review of Entomology, 2012
The nuclear receptors (NRs) of metazoans are an ancient family of transcription factors defined by conserved DNA- and ligand-binding domains (DBDs and LBDs, respectively). The Drosophila melanogaster genome project revealed 18 canonical NRs (with DBDs and LBDs both present) and 3 receptors with the DBD only.
Susan E, Fahrbach +2 more
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The nuclear receptors (NRs) of metazoans are an ancient family of transcription factors defined by conserved DNA- and ligand-binding domains (DBDs and LBDs, respectively). The Drosophila melanogaster genome project revealed 18 canonical NRs (with DBDs and LBDs both present) and 3 receptors with the DBD only.
Susan E, Fahrbach +2 more
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Dimerization of Nuclear Receptors
2013Multicellular organisms require specific intercellular communication to properly organize the complex body plan during embryogenesis and maintain its properties and functions during the entire life. While growth factors, neurotransmitters, and peptide hormones bind to membrane receptors, thereby inducing the activity of intracellular kinase cascades or
Pierre, Germain, William, Bourguet
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Biochemistry (Moscow), 2001
Current opinions on the potential role of orphan nuclear retinoid receptors of the ROR/RZR subfamily in regulatory activities of the pineal gland hormone melatonin are reviewed. The mechanisms of receptor--DNA interactions and known coactivators, tissue peculiarities of the expression of different receptor isoforms, and its regulation are described ...
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Current opinions on the potential role of orphan nuclear retinoid receptors of the ROR/RZR subfamily in regulatory activities of the pineal gland hormone melatonin are reviewed. The mechanisms of receptor--DNA interactions and known coactivators, tissue peculiarities of the expression of different receptor isoforms, and its regulation are described ...
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Nuclear receptors and disease: androgen receptor
Essays in Biochemistry, 2004The androgen receptor (AR) protein regulates transcription of certain genes. Usually this depends upon a central DNA-binding domain that permits the binding of androgen–AR complexes to regulatory DNA sequences near or in a target gene. The AR also has a C-terminal ligand-binding domain and an Nterminal transcription modulatory domain.
Bruce, Gottlieb +4 more
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Nuclear receptors in disease: the oestrogen receptors
Essays in Biochemistry, 2004For several decades, it has been known that oestrogens are essential for human health. The discovery that there are two oestrogen receptors (ERs), ERalpha and ERbeta, has facilitated our understanding of how the hormone exerts its physiological effects.
Maria, Nilsson +2 more
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Nuclear Receptors in Liver Disease Δ
Hepatology, 2011Abstract Nuclear receptors are ligand-activated transcriptional regulators of several key aspects of hepatic physiology and pathophysiology. As such, nuclear receptors control a large variety of metabolic processes including hepatic lipid metabolism, drug disposition, bile acid homeostasis, as ...
Wagner +3 more
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Annals of the New York Academy of Sciences, 2007
Abstract: Nuclear receptors (NRs) represent a class of ligand‐dependent and ‐independent transcription factors with importance to the regulation of development, reproduction, and metabolism. The emergence of new understanding of the structure, function, and role in disease of NRs provides new insights into the interaction between genetics and the ...
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Abstract: Nuclear receptors (NRs) represent a class of ligand‐dependent and ‐independent transcription factors with importance to the regulation of development, reproduction, and metabolism. The emergence of new understanding of the structure, function, and role in disease of NRs provides new insights into the interaction between genetics and the ...
openaire +2 more sources