Results 271 to 280 of about 855,861 (301)
Some of the next articles are maybe not open access.
Ubiquitination of nuclear receptors
Clinical Science, 2017Nuclear receptors (NRs) are cellular proteins, which upon ligand activation, act to exert regulatory control over transcription and subsequent expression. Organized via systemic classification into seven subfamilies, NRs partake in modulating a vast expanse of physiological functions essential for maintenance of life.
Jimmy, El Hokayem +3 more
openaire +2 more sources
Nuclear Receptors in Energy Metabolism
2022Nuclear receptors are master regulators of energy metabolism through the conversion of extracellular signals into gene expression signatures. The function of the respective nuclear receptor is tissue specific, signal and co-factor dependent. While normal nuclear receptor function is central to metabolic physiology, aberrant nuclear receptor signaling ...
Walth-Hummel, A.A., Herzig, S., Rohm, M.
openaire +3 more sources
Annals of the New York Academy of Sciences, 2007
Abstract: Nuclear receptors (NRs) represent a class of ligand‐dependent and ‐independent transcription factors with importance to the regulation of development, reproduction, and metabolism. The emergence of new understanding of the structure, function, and role in disease of NRs provides new insights into the interaction between genetics and the ...
openaire +2 more sources
Abstract: Nuclear receptors (NRs) represent a class of ligand‐dependent and ‐independent transcription factors with importance to the regulation of development, reproduction, and metabolism. The emergence of new understanding of the structure, function, and role in disease of NRs provides new insights into the interaction between genetics and the ...
openaire +2 more sources
Nuclear receptors and disease: androgen receptor
Essays in Biochemistry, 2004The androgen receptor (AR) protein regulates transcription of certain genes. Usually this depends upon a central DNA-binding domain that permits the binding of androgen–AR complexes to regulatory DNA sequences near or in a target gene. The AR also has a C-terminal ligand-binding domain and an Nterminal transcription modulatory domain.
Bruce, Gottlieb +4 more
openaire +2 more sources
Nuclear receptors in disease: the oestrogen receptors
Essays in Biochemistry, 2004For several decades, it has been known that oestrogens are essential for human health. The discovery that there are two oestrogen receptors (ERs), ERalpha and ERbeta, has facilitated our understanding of how the hormone exerts its physiological effects.
Maria, Nilsson +2 more
openaire +2 more sources
Biochemistry (Moscow), 2001
Current opinions on the potential role of orphan nuclear retinoid receptors of the ROR/RZR subfamily in regulatory activities of the pineal gland hormone melatonin are reviewed. The mechanisms of receptor--DNA interactions and known coactivators, tissue peculiarities of the expression of different receptor isoforms, and its regulation are described ...
openaire +2 more sources
Current opinions on the potential role of orphan nuclear retinoid receptors of the ROR/RZR subfamily in regulatory activities of the pineal gland hormone melatonin are reviewed. The mechanisms of receptor--DNA interactions and known coactivators, tissue peculiarities of the expression of different receptor isoforms, and its regulation are described ...
openaire +2 more sources
Dimerization of Nuclear Receptors
2013Multicellular organisms require specific intercellular communication to properly organize the complex body plan during embryogenesis and maintain its properties and functions during the entire life. While growth factors, neurotransmitters, and peptide hormones bind to membrane receptors, thereby inducing the activity of intracellular kinase cascades or
Pierre, Germain, William, Bourguet
openaire +2 more sources
Nuclear Receptors in Liver Disease Δ
Hepatology, 2011Abstract Nuclear receptors are ligand-activated transcriptional regulators of several key aspects of hepatic physiology and pathophysiology. As such, nuclear receptors control a large variety of metabolic processes including hepatic lipid metabolism, drug disposition, bile acid homeostasis, as ...
Wagner +3 more
openaire +3 more sources
1999
Abstract The steroid / nuclear receptor superfamily is a large and growing group of transcription factors that are studied by a large and varied number of basic and clinical researchers. The first two chapters describe the evolutionary biology of the superfamily and explain how to clone and characterize new receptors. Chapter 3 shows how
openaire +1 more source
Abstract The steroid / nuclear receptor superfamily is a large and growing group of transcription factors that are studied by a large and varied number of basic and clinical researchers. The first two chapters describe the evolutionary biology of the superfamily and explain how to clone and characterize new receptors. Chapter 3 shows how
openaire +1 more source
Transcriptional control of energy metabolism by nuclear receptors
Nature Reviews Molecular Cell Biology, 2022Charlotte Scholtes, Vincent Giguère
exaly