Results 81 to 90 of about 146,944 (315)

Sensitivity of the 252Cf(sf) neutron observables to the FREYA input yield functions Y(A, Z, TKE)

EPJ Web of Conferences, 2017
Within the framework of the fission event generator FREYA, we are studying the sensitivity of various neutron observables to the yield distribution Y (A,Z,TKE) used as input to the code.
Randrup Jørgen, Talou Patrick, Vogt Ramona   +2 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

A topological route to engineering robust and bright supersymmetric laser arrays

Communications Physics
In recent years, several proposals that leverage principles from condensed matter and high-energy physics for engineering laser arrays have been put forward.
Soujanya Datta, Mohammadmahdi Alizadeh, Ramy El-Ganainy, Krishanu Roychowdhury   +3 more
doaj   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Baryon-number — flavor separation in the topological expansion of QCD

Journal of High Energy Physics
Gauge invariance of QCD dictates the presence of string junctions in the wave functions of baryons. In high-energy inclusive processes, these baryon junctions have been predicted to induce the separation of the flows of baryon number and flavor.
David Frenklakh, Dmitri Kharzeev, Giancarlo Rossi, Gabriele Veneziano   +3 more
doaj   +1 more source

Part III. Construction of Nuclear Potential from Pion Theory [PDF]

, 1956
Shigeru Machida, Toshiyuki Toyoda
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Brickwall in rotating BTZ: a dip-ramp-plateau story

Journal of High Energy Physics
In this article, building on our recent investigations and motivated by the fuzzball-paradigm, we explore normal modes of a probe massless scalar field in the rotating BTZ-geometry in an asymptotically AdS spacetime and correspondingly obtain the ...
Suman Das, Arnab Kundu
doaj   +1 more source

Punctuation Patterns in Finnegans Wake by James Joyce Are Largely Translation-Invariant

Entropy
The complexity characteristics of texts written in natural languages are significantly related to the rules of punctuation. In particular, the distances between punctuation marks measured by the number of words quite universally follow the family of ...
Krzysztof Bartnicki, Stanisław Drożdż, Jarosław Kwapień, Tomasz Stanisz   +3 more
doaj   +1 more source