Results 111 to 120 of about 624,823 (322)

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Algorithmic Cooling of Spins: A Practicable Method for Increasing Polarization

, 2004
An efficient technique to generate ensembles of spins that are highly polarized by external magnetic fields is the Holy Grail in Nuclear Magnetic Resonance (NMR) spectroscopy.
Fernandez, Jose M., Lloyd, Seth, Mor, Tal, Roychowdhury, Vwani   +3 more
core   +3 more sources

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Current NMR Techniques for Structure-Based Drug Discovery

Molecules, 2018
A variety of nuclear magnetic resonance (NMR) applications have been developed for structure-based drug discovery (SBDD). NMR provides many advantages over other methods, such as the ability to directly observe chemical compounds and target biomolecules,
Toshihiko Sugiki, Kyoko Furuita, Toshimichi Fujiwara, Chojiro Kojima   +3 more
doaj   +1 more source

From the stable to the exotic: clustering in light nuclei

, 2015
A great deal of research work has been undertaken in alpha-clustering study since the pioneering discovery of 12C+12C molecular resonances half a century ago. Our knowledge on physics of nuclear molecules has increased considerably and nuclear clustering
A Goasduff, A Tohsaki, C Beck, C Bhattacharya, D Lebhertz, DG Jenkins, DJ Marin-Lambarri, E Uegaki, F Hoyle, H Horiuchi, HG Bohlen, J Manfredi, M Dufour, M Freer, M Freer, M Freer, M Freer, M Freer, M Furutachi, M Girod, M Itoh, M Milin, M Rousseau, MD Salsac, N Curtis, OS Kirsebom, P Chevallier, P Descouvemont, R Bijker, SJ Sanders, T Suhara, TK Rana, VI Zagrebaev, W Broniowski, W Oertzen von, W Oertzen von, W Oertzen von, W Oertzen von, W Oerzten von, WR Zimmerman, Y Funaki, Y Kanada-En’yo   +41 more
core   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

A Design and Implementation of Power Transfer Equipment Based on Fault Diagnostics in System Level

Chemical Engineering Transactions, 2013
This paper presents a design and implementation of a certain automatic power transfer equipment adopted by a power supply system serving for nuclear industry.
M. Luo, R. Kang
doaj   +1 more source

Indirect techniques in nuclear astrophysics. Asymptotic Normalization Coefficient and Trojan Horse

, 2005
Owing to the presence of the Coulomb barrier at astrophysically relevant kinetic energies it is very difficult, or sometimes impossible, to measure astrophysical reaction rates in the laboratory.
A. Momotyuk, A. Tumino, A.M. Mukhamedzhanov, Angulo, B. Roeder, B.F. Irgaziev, Baur, Blokhintsev, C. Spitaleri, E. Johnson, G. Rogachev, K. Kemper, Kubono, L. Lamia, L.D. Blokhintsev, M. Gulino, M. La Cognata, Mukhamedzhanov, Mukhamedzhanov, R.E. Tribble, R.G. Pizzone, S. Brown, S. Cherubini, S. Romano, Spitaleri, Spitaleri, Typel, V. Burjan, V. Kroha, V.Z. Goldberg, Xu   +30 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A comprehensive review on nanofluids: Synthesis, cutting-edge applications, and future prospects

International Journal of Thermofluids
Nanofluids, which are fluid suspensions containing nanoparticles, exhibit remarkable property enhancements even at low nanoparticle concentrations. Much of the research on nanofluids aims to understand their behavior for applications where heat transfer ...
Habib Ben Bacha, Naeem Ullah, Aamir Hamid, Nehad Ali Shah   +3 more
doaj   +1 more source