Results 111 to 120 of about 519,067 (307)

Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding

FEBS Open Bio, EarlyView.
The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla, Faiza Abbas, Luigia Rossi, Mauro Magnani, Sara Biagiotti   +4 more
wiley   +1 more source

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Coherent gamma photon generation in a Bose–Einstein condensate of 135mCs

Physics Letters B, 2018
We have identified a mechanism of collective nuclear de-excitation in a Bose–Einstein condensate of 135Cs atoms in their isomeric state, 135mCs, suitable for the generation of coherent gamma photons.
Luca Marmugi, Philip M. Walker, Ferruccio Renzoni   +2 more
doaj  

Estimating centrality in heavy-ion collisions using Transfer Learning technique [PDF]

arXiv
In this study, we explore the applicability of Transfer Learning techniques for estimating collision centrality in terms of the number of participants ($N_{\rm part}$) in high-energy heavy-ion collisions. In the present work, we leverage popular pre-trained CNN models such as VGG16, ResNet50, and DenseNet121 to determine $N_{\rm part}$ in Au+Au ...
arxiv  

Mitochondrial replacement therapy and assisted reproductive technology: A paradigm shift toward treatment of genetic diseases in gametes or in early embryos

Reproductive Medicine and Biology, 2018
Background Recent technological development allows nearly complete replacement of the cytoplasm of egg/embryo, eliminating the transmission of undesired defective mitochondria (mutated mitochondrial DNA: mtDNA) for patients with inherited mitochondrial ...
Masahito Tachibana, Takashi Kuno, Nobuo Yaegashi   +2 more
doaj   +1 more source

Multi‐institutional study on image quality for a novel CBCT solution on O‐ring linac

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction This work presents a multi‐institutional study on image quality provided by a novel cone beam computed tomography (CBCT). The main goal is to investigate the consistency of imaging performance across multiple institutions.
Luis Agulles‐Pedrós, R. Lee MacDonald, Amanda Jean Cherpak, Nayha Dixit, Lei Dong, Tianyu Zhao, Kundan Thind, Anthony Doemer, Boon‐Keng Teo, Shiqin Su, Alexander Moncion, James L. Robar   +11 more
wiley   +1 more source

Commissioning evaluation of a deviceless 4DCT scanner

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The utilization of four‐dimensional computed tomography (4DCT) for radiation therapy has not seen major advances to the method of data binning since shortly after inception. Recently there is increased interest in the utilization of an alternative binning method rather than more established techniques.
Hunter Tillery, Cheyann Windsor, Christopher Aguilera   +2 more
wiley   +1 more source

Detecting water-protein chemical exchange in membrane-bound proteins/peptides by solid-state NMR spectroscopy

Magnetic Resonance Letters, 2021
Water plays an important role in many essential biological processes of membrane proteins in hydrated lipid environments. In general, the 1H polarization transfers between water molecules and site-specific protons in proteins can be classified as ...
Rongfu Zhang, Timothy A. Cross, Riqiang Fu   +2 more
doaj