Results 81 to 90 of about 624,823 (322)

Hadrons and Nuclei

, 2019
This document is one of a series of whitepapers from the USQCD collaboration. Here, we discuss opportunities for lattice QCD calculations related to the structure and spectroscopy of hadrons and nuclei.
Detmold, William, Dudek, Jozef J., Edwards, Robert G., Engelhardt, Michael, Lin, Huey-Wen, Meinel, Stefan, Orginos, Kostas, Shanahan, Phiala   +7 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Data transfers for nuclear reactor multiphysics studies using the MOOSE framework

Frontiers in Nuclear Engineering
High fidelity simulations of nuclear systems generally require a multi-dimensional representation of the system. Advanced nuclear reactor cores are governed by multiple physical phenomena which should be all be resolved, and the coupling of these physics
Guillaume L. Giudicelli, Guillaume L. Giudicelli, Fande Kong, Roy Stogner, Logan Harbour, Derek Gaston, Alexander Lindsay, Zachary Prince, Lise Charlot, Stefano Terlizzi, Mahmoud Eltawila, April Novak   +11 more
doaj   +1 more source

Biotechnological bases of the development of cloned pig embryos

Вавиловский журнал генетики и селекции, 2019
The term ‘clone’ in animal biotechnology refers to an organism derived from non-sexual reproduction, which is both a direct offspring and a genetic copy of the parent organism.
A. V. Lopukhov, G. N. Singina, N. A. Zinovieva   +2 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Perspectives of Nuclear Physics in Europe: NuPECC Long Range Plan 2010 [PDF]

, 2010
The goal of this European Science Foundation Forward Look into the future of Nuclear Physics is to bring together the entire Nuclear Physics community in Europe to formulate a coherent plan of the best way to develop the field in the coming decade and ...
Bracco, A., Chomaz, P., Gaardhøje, J.J., Heenen, P.-H., Kaiser, R., Korner, G.E., MacGregor, D., Makarow, M., Rosner, G., Widmann, E.   +9 more
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Applications of somatic cell nuclear transfer in goats

Journal of Advanced Veterinary and Animal Research, 2014
A number of animals with genetically identical appearance can be produced by somatic cell nuclear transfer (SCNT). From current advancement of SCNT and molecular techniques, production of a transgenic animal becomes easier. Although cloning efficiency in
Ton Yoisungnern, Ashit Kumar Paul
doaj   +1 more source

The magic nature of 132Sn explored through the single-particle states of 133Sn

, 2010
Atomic nuclei have a shell structure where nuclei with 'magic numbers' of neutrons and protons are analogous to the noble gases in atomic physics. Only ten nuclei with the standard magic numbers of both neutrons and protons have so far been observed. The
A Strömich, A. S. Adekola, B. H. Moazen, C Barbieri, C Ellegaard, C. D. Nesaraja, C. Harlin, D. Shapira, D. W. Bardayan, DW Stracener, DY Pang, F. M. Nunes, GJ Kramer, H Grawe, IJ Thompson, J Terasaki, J. A. Cizewski, J. C. Blackmon, J. F. Liang, J. F. Shriner, J. S. Thomas, JJ Cowan, JL Wiza, JS Thomas, K Hirota, K. A. Chipps, K. L. Jones, K. Y. Chae, KE Rehm, L Coraggio, L. Erikson, M. S. Smith, MG Mayer, MP Kartamyshev, N. P. Patterson, P Hoff, R. Hatarik, R. Kapler, R. L. Kozub, R. Livesay, RL Kozub, RV Reid, S Sarkar, S. D. Pain, SD Pain, T. P. Swan, W Urban, Z. Ma   +47 more
core   +1 more source