Results 81 to 90 of about 146,303 (307)

Transfer characteristics of a lithium chloride–potassium chloride molten salt

Nuclear Engineering and Technology, 2017
Pyroprocessing is an alternative method of reprocessing spent fuel, usually involving the dissolving spent fuel in a molten salt media. The National Nuclear Laboratory designed, built, and commissioned a molten salt dynamics rig to investigate the ...
Eve Mullen, Ross Harris, Dave Graham, Chris Rhodes, Zara Hodgson   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Interspecies Somatic Cell Nuclear Transfer Technique for Researching Dog Cloning and Embryonic Stem Cells

Asian-Australasian Journal of Animal Sciences, 2010
Large quantities of high-quality recipient oocytes with uniform cytoplasm are needed for research in the promising field of somatic cell nuclear transfer (SCNT) and embryonic stem cell research. In canines, however, it is difficult to obtain large quantities of oocytes because each donor produces a limited number of mature oocytes in vivo.
Satoshi Sugimura, Eimei Sato
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Implications of using nanoparticles on the performance and safety of nuclear systems

, 2023
Nanotechnology, and particularly nanoparticles (NPs), command significant attention across diverse fields such as medicine, chemistry, and engineering. NPs are integrated into a base material through various techniques, such as dispersion, coating, and ...
Zubair, Muhammad, Elgack, Omarelfarouq, Said, Zafar (R21100)   +2 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

2-(Butylamino)-6-chloro-4-[3-(7-chloro-4-quinolylamino)propylamino]-1,3,5-triazine

Molbank
We herein report the synthesis of a 7-chloro-aminoquinoline triazine conjugate. The s-triazine library was generated by stepwise nucleophilic substitution of cyanuric chloride with butylamine.
Zimo Ren, Yuzhu Guo, Yang Xiao, Alessandra Gianoncelli, Paolo Coghi, Giovanni Ribaudo   +5 more
doaj   +1 more source

Development of chimaeras produced from highly asynchronous mouse embryos using nuclear transfer technique.

The Japanese journal of animal reproduction, 1989
マウス2細胞期(野生色)胚の片側割球の核を2あるいは8細胞期(アルビノ)胚の核と置換してキメラ2細胞期胚を作出し,異なる発生ステージ間の胚からキメラマウスの作出を試みた。また,産子の毛色パターンから移植核の発生動態についても考察した。得られた結果は次ぎの通りである。1)2細胞期胚の片側割球の核を2あるいは8細胞期胚の核と置換したいずれの場合,キメラ胚の胚盤胞並びに移植後の産子の発生率は,それぞれ81%-90%および59-76%といずれも高い値であった。2)2細胞期同士で核置換したキメラ2細胞期胚からは,高率にキメラ個体がえられた。しかし,8細胞期胚の核で置換するとキメラ出現率は減少し,野生色個体は逆に増加した。3)したがって,8細胞期胚の核を持つ2細胞期片側割球由来の細胞は ...
KONO, Tomohiro, TSUNODA, Yukio, WATANABE, Tadao, NAKAHARA, Tatsuo   +3 more
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Assessment of CTF boiling transition and critical heat flux modeling capabilities using the OECD/NRC BFBT and PSBT benchmark databases

, 2011
The need to refine models for best-estimate calculations, based on good-quality experimental data, has been expressed in many recent meetings in the field of nuclear applications.
Avramova, Maria, Cuervo Gómez, Diana
core