Results 131 to 140 of about 6,071,343 (411)

Dendrimers in gene delivery [PDF]

, 2005
Dendrimers have unique molecular architectures and properties that make them attractive materials for the development of nanomedicines. Key properties such as defined architecture and a high ratio of multivalent surface moieties to molecular volume also ...
Dufès, Christine, Schätzlein, Andreas G., Uchegbu, Ijeoma F.   +2 more
core   +1 more source

Integrated microfluidic systems with sample preparation and nucleic acid amplification.

Lab on a Chip, 2019
Rapid, efficient and accurate nucleic acid molecule detection is important in the screening of diseases and pathogens, yet remains a limiting factor at point of care (POC) treatment.
Juxin Yin, Yuanjie Suo, Zheyu Zou, Jingjing Sun, Shan Zhang, Ben Wang, Yawei Xu, D. Darland, J. Zhao, Y. Mu   +9 more
semanticscholar   +1 more source

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

Advanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi, Munevver Akdeniz, Awel Olsido Ahmed, Mine Altunbek, Omer Aydin   +4 more
wiley   +1 more source

The accumulation of orotic acid by a pyrimidineless mutant of Neurospora [PDF]

, 1948
The discovery of orotic acid (1,2-carboxyuracil) in cow's milk by Biscaro and Belloni (1), followed by its identification and synthesis (2-4), led to a number of speculations as to its biological origin and significance (,3,5,6).
Houlahan, Mary B., Mitchell, Herschel K., Nyc, Joseph F.   +2 more
core  

Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications [PDF]

, 2010
Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides.
Ambros, Bartel, Braasch, Bramsen, Breaker, Brown, Castoldi, Crooke, Darfeuille, Darfeuille, Elbashir, Ellington, Elmén, Elmén, Famulok, Hannon, Jadhav, Jakobsen, Jayasena, Jepsen, Kauppinen, Klug, Koch, Koshkin, Koshkin, Lebars, Mello, Mook, Nielsen, Nimjee, Obika, Obika, Opalinska, Petersen, Petersen, Primo, Rimmele, Santoro, Schmidt, Schubert, Schubert, Singh, Stoltenburg, Tuerk, Veedu, Veedu, Veedu, Veedu, Vester, Vester, Válóczi, Wahlestedt, Wengel, Wienholds, Ørum   +54 more
core   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

eLife, 2013
Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which multiple same-strand substitutions at C:G pairs spaced one to several hundred nucleotides apart are clustered over kilobase-sized regions, often associated with ...
Benjamin JM Taylor, Serena Nik-Zainal, Yee Ling Wu, Lucy A Stebbings, Keiran Raine, Peter J Campbell, Cristina Rada, Michael R Stratton, Michael S Neuberger   +8 more
doaj   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Accurate prediction of nucleic acid and protein-nucleic acid complexes using RoseTTAFoldNA

bioRxiv, 2022
M. Baek, Ryan McHugh, I. Anishchenko, D. Baker, F. DiMaio   +4 more
semanticscholar   +1 more source