Results 51 to 60 of about 2,571,740 (262)
DNA replication initiation drives focal mutagenesis and rearrangements in human cancers
Nature CommunicationsThe rate and pattern of mutagenesis in cancer genomes is significantly influenced by DNA accessibility and active biological processes. Here we show that efficient sites of replication initiation drive and modulate specific mutational processes in cancer.
Pierre Murat +2 more
doaj +1 more source
Are Signal Peptides Hidden Regulators of Neurodegenerative Disease?
BiomedicinesCanonical signal peptides (SPs) are short N-terminal sequences that direct nascent proteins into the secretory pathway, but their role extends far beyond protein targeting.
Maciej Karbownik +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Excess Dally-like Induces Malformation of Drosophila Legs
CellsGlypicans are closely associated with organ development and tumorigenesis in animals. Dally-like (Dlp), a membrane-bound glypican, plays pivotal roles in various biological processes in Drosophila.
Xubo Zhang +7 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Nucleic Acid (Patent US 2009/0019559 A1) [PDF]
, 2009 The invention relates to nucleic acid derived from Perkinsus marinus which encodes a 9-elongase, a Delta8-desaturase and a Delta5-desaturase enzyme.
Sayanova, O. V. +2 more
core
Developing methods to study conformational changes in RNA crystals using a photocaged ligand
Frontiers in Molecular Biosciences, 2022 Crystallographic observation of structural changes in real time requires that those changes be uniform both spatially and temporally. A primary challenge with time-resolved ligand-mixing diffraction experiments is asynchrony caused by variable factors ...
Hyun Kyung Lee +8 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Nucleic Acid (Patent WO 2007/093776 A2) [PDF]
, 2007 The invention relates to nucleic acid derived from Perkinsus marinus which encodes a 9-elongase, a ?8-desaturase and a ?5-desaturase enzyme.
Sayanova, O. V. +2 more
core
New peptide nucleic acids for biotechnological applications [PDF]
, 2010 In the present study was designed and realized a new similar to the PNA. It is a chiral nucleo-γ-peptide, dabPNA, isomer of the aegPNA unit and characterized by a 2,4-diaminobutyric acid (DABA)-based backbone carrying the carboxymethylated nucleobase on ...
Castiglione, Mariangela
core +1 more source