Results 41 to 50 of about 2,571,740 (262)
Communications BiologyLipid nanoparticles (LNPs) have emerged as promising platforms for efficient in vivo mRNA delivery owing to advancements in ionizable lipids. However, maintaining the thermostability of mRNA/LNP systems remains challenging. While the importance of only a
Kazuki Hashiba +8 more
doaj +1 more source
Antiviral and Immunoenhancing Properties of 7-Thia-8-Oxoguanosine and Related Guanosine Analogues
Canadian Journal of Infectious Diseases, 1992 7-thia-8-oxoguanosine (TOGuo) is the first reported structure of a family of modified guanosine analogues exhibiting antiviral activity in rodent models.
Donald F Smee +8 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
SWAMNA: a comprehensive platform for analysis of nucleic acid modifications [PDF]
, 2023 The interest in MS-based analysis of modified nucleic acids is increasing due to the application of nucleic acids in therapeutics. However, there are few available integrated platforms for characterizing nucleic acid modifications.
Joanna K., Lempiäinen +11 more
core +3 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Fluorinated peptide nucleic acid [PDF]
, 2003 The fluorinated olefinic peptide nucleic acid analogue (F-OPA) monomer containing the base thymine was synthesised in 13 steps. PNAs containing this unit were prepared and their pairing properties assessed by means of UV-melting ...
Marcel Hollenstein +5 more
core +1 more source
Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA
Cell Reports, 2015 We present the crystal structure of the junction-resolving enzyme GEN1 bound to DNA at 2.5 Å resolution. The structure of the GEN1 protein reveals it to have an elaborated FEN-XPG family fold that is modified for its role in four-way junction resolution.
Yijin Liu +5 more
doaj +1 more source
DNA Composites and Applications in Bioanalysis
Advanced Sensor Research, 2023 DNA combined with other functional nanomaterials plays crucial roles in biomedical areas, including bio‐detection, bioimaging, as well as disease diagnosis and treatment.
Zheng Fang, Min Li, Xiaolei Zuo
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
The infectivity and inactivation of nucleic acid preparations from tobacco mosaic virus [PDF]
, 1959 The infectivity of nucleic acid preparations made by disrupting tobacco mosaic virus with phenol was increased, relative to that of intact virus, by keeping test plants in darkness or at 37° for some time before they were inoculated.
Pirie, N. W., Bawden, F. C.
core +1 more source