Results 21 to 30 of about 2,571,740 (262)
Nature Communications, 2022 Neutral networks, which are sets of genotypes connected via single mutations that share the same phenotype, are important for evolvability. Here, the authors provide experimental evidence of a neutral network in an RNA enzyme using a high-throughput ...
Rachapun Rotrattanadumrong +1 more
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Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Christina Troiber +3 more
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Emerging Microbes and Infections, 2021 While DNA prime-protein boost vaccination approach has been widely used in preclinical and clinical studies especially in the field of HIV vaccine development, the exact role of DNA immunization has not been fully identified.
Haiying Li +5 more
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Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM) [PDF]
, 2003 Pyrrolidine-amide oligonucleotide mimics (POM) 1 were designed to be stereochemically and conformationally similar to natural nucleic acids, but with an oppositely charged, cationic backbone.
Tan, T. H. Samuel +14 more
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Investigating the mechanism of action of hemofugal and blood-stasis-expelling soup in the treatment of coronary heart disease based on network pharmacology [PDF]
BIO Web of ConferencesObjective: To investigate the mechanism of action of Xuefu yuyuxu Tang in the treatment of Coronary Heart Disease (CHD) based on network-based pharmacology.
·yusuf Arslan, Ma Yun, Wang Qi
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A novel splice variant of the human MSTN gene encodes a myostatin‐specific myostatin inhibitor
Journal of Cachexia, Sarcopenia and Muscle, 2023 Background Myostatin, encoded by the MSTN gene comprising 3 exons, is a potent negative regulator of skeletal muscle growth. Although a variety of myostatin inhibitors have been invented for increasing muscle mass in muscle wasting diseases, no effective
Kazuhiro Maeta +3 more
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eLife, 2014 Cytidine deaminases are single stranded DNA mutators diversifying antibodies and restricting viral infection. Improper access to the genome leads to translocations and mutations in B cells and contributes to the mutation landscape in cancer, such as ...
Benjamin JM Taylor +2 more
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On-Chip DNA Methylation Analysis Using Osmium Complexation
Journal of Nucleic Acids, 2011 The development of a reaction for detecting the presence/absence of one methyl group in a long DNA strand is a chemically and biologically challenging research subject.
Kaori Sugizaki +2 more
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Identification and differentiation among chicken's, duck's, quail's, rabbit's and turkey's meat using PCR-RFLP technique [PDF]
Biotechnology in Animal Husbandry, 2015 PCR-RFLP technique was developed for identification and differentiation among chicken's, duck's, quail's, rabbit's and turkey's meat. DNA from small amount of muscles (0.05 g) was extracted and a region of mitochondrial DNA (cytochrome-b gene) in chicken,
Abdel-Rahman S.M. +2 more
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Novel Selenium-modified Nucleic Acids For Structural and Functional Studies [PDF]
, 2015 Nucleic acids, as one of the most important macromolecules in living systems, play critical roles in storing, transferring, regulating genetic information, directing proteins synthesis, and catalysis. Understanding the structure of nucleic acid can bring
Jiang, Sibo
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