Results 21 to 30 of about 815,217 (265)

A novel splice variant of the human MSTN gene encodes a myostatin‐specific myostatin inhibitor

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Myostatin, encoded by the MSTN gene comprising 3 exons, is a potent negative regulator of skeletal muscle growth. Although a variety of myostatin inhibitors have been invented for increasing muscle mass in muscle wasting diseases, no effective
Kazuhiro Maeta, Manal Farea, Hisahide Nishio, Masafumi Matsuo   +3 more
doaj   +1 more source

Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes

eLife, 2014
Cytidine deaminases are single stranded DNA mutators diversifying antibodies and restricting viral infection. Improper access to the genome leads to translocations and mutations in B cells and contributes to the mutation landscape in cancer, such as ...
Benjamin JM Taylor, Yee Ling Wu, Cristina Rada   +2 more
doaj   +1 more source

On-Chip DNA Methylation Analysis Using Osmium Complexation

Journal of Nucleic Acids, 2011
The development of a reaction for detecting the presence/absence of one methyl group in a long DNA strand is a chemically and biologically challenging research subject.
Kaori Sugizaki, Tadashi Umemoto, Akimitsu Okamoto   +2 more
doaj   +1 more source

Identification and differentiation among chicken's, duck's, quail's, rabbit's and turkey's meat using PCR-RFLP technique [PDF]

Biotechnology in Animal Husbandry, 2015
PCR-RFLP technique was developed for identification and differentiation among chicken's, duck's, quail's, rabbit's and turkey's meat. DNA from small amount of muscles (0.05 g) was extracted and a region of mitochondrial DNA (cytochrome-b gene) in chicken,
Abdel-Rahman S.M., Elmaghraby A.M., Haggag A.S.   +2 more
doaj  

Development of siRNAs targeting interferon beta as a novel therapeutic approach for adult and juvenile dermatomyositis

Frontiers in Immunology
BackgroundA key feature of the autoimmune conditions adult and juvenile dermatomyositis (DM/JDM) is the correlation of interferon (IFN) beta induction with disease initiation and activity. Our aim was to establish a short interfering RNA (siRNA) approach
Joanna E. Parkes, Andrés F. Correa-Sánchez, Inês Fial, Isaac Tam, Kaladevi Selvam, Mark Cunningham, Nick Lench, Peter L. Oliver   +7 more
doaj   +1 more source

Receptor of Advanced Glycation End Products Deficiency Attenuates Cisplatin-Induced Acute Nephrotoxicity by Inhibiting Apoptosis, Inflammation and Restoring Fatty Acid Oxidation

Frontiers in Pharmacology, 2022
Cisplatin is a widely used and potent anti-neoplastic agent, but severe and inescapable side effects in multiple normal tissues and organs limit its application, especially nephrotoxicity.
Qiang Wang, Qiang Wang, Yuemei Xi, Yuemei Xi, Binyang Chen, Binyang Chen, Hairong Zhao, Hairong Zhao, Wei Yu, Wei Yu, De Xie, De Xie, Weidong Liu, Weidong Liu, Furong He, Furong He, Chenxi Xu, Chenxi Xu, Jidong Cheng, Jidong Cheng   +19 more
doaj   +1 more source

Toxicity Evaluation of Potassium Sorbate In Vivo with Drosophila Melanogaster

Insects
Potassium sorbate (PS) is a preservative widely used in the food, pharmaceutical, and cosmetics industries. Improper and careless use of PS can lead to various health issues and potential environmental problems.
Xubo Zhang, Qian Zhang, Xiaoxuan Song, Wanchen Yang, Andi Cheng, Jianzhen Zhang, Wei Dong   +6 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Overcoming thermostability challenges in mRNA–lipid nanoparticle systems with piperidine-based ionizable lipids

Communications Biology
Lipid nanoparticles (LNPs) have emerged as promising platforms for efficient in vivo mRNA delivery owing to advancements in ionizable lipids. However, maintaining the thermostability of mRNA/LNP systems remains challenging. While the importance of only a
Kazuki Hashiba, Masamitsu Taguchi, Sachiko Sakamoto, Ayaka Otsu, Yoshiki Maeda, Hirofumi Ebe, Arimichi Okazaki, Hideyoshi Harashima, Yusuke Sato   +8 more
doaj   +1 more source