Results 31 to 40 of about 815,217 (265)

Conformational switches control early maturation of the eukaryotic small ribosomal subunit

eLife, 2019
Eukaryotic ribosome biogenesis is initiated with the transcription of pre-ribosomal RNA at the 5’ external transcribed spacer, which directs the early association of assembly factors but is absent from the mature ribosome.
Mirjam Hunziker, Jonas Barandun, Olga Buzovetsky, Caitlin Steckler, Henrik Molina, Sebastian Klinge   +5 more
doaj   +1 more source

Comprehensive analysis reveals a 5-gene signature and immune cell infiltration in Alzheimer’s disease with qPCR validation

Frontiers in Genetics, 2022
Over 50 million people around the world currently are suffering from Alzheimer’s disease (AD) without any effective therapy. Neuroinflammation plays a pivotal role in AD, which leads us to probe the profile of immune cell infiltration in AD.
Fanmao Jin, Yuemei Xi, Yuemei Xi, De Xie, De Xie, Qiang Wang, Qiang Wang   +6 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213

EMBO Reports
Innate immunity senses microbial ligands known as pathogen-associated molecular patterns (PAMPs). Except for nucleic acids, PAMPs are exceedingly taxa-specific, thus enabling pattern recognition receptors to detect cognate pathogens while ignoring others.
Ana Crespillo-Casado, Prathyush Pothukuchi, Katerina Naydenova, Matthew C J Yip, Janet M Young, Jerome Boulanger, Vimisha Dharamdasani, Ceara Harper, Pierre-Mehdi Hammoudi, Elsje G Otten, Keith Boyle, Mayuri Gogoi, Harmit S Malik, Felix Randow   +13 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Antiviral and Immunoenhancing Properties of 7-Thia-8-Oxoguanosine and Related Guanosine Analogues

Canadian Journal of Infectious Diseases, 1992
7-thia-8-oxoguanosine (TOGuo) is the first reported structure of a family of modified guanosine analogues exhibiting antiviral activity in rodent models.
Donald F Smee, Howard B Cottam, Brahma S Sharma, Ganesh D Kini, Ganapathi R Revankar, Emmanuel A Ojo-Amaize, Robert W Sidwell, Weldon B Jolley, Roland K Robins   +8 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Are Signal Peptides Hidden Regulators of Neurodegenerative Disease?

Biomedicines
Canonical signal peptides (SPs) are short N-terminal sequences that direct nascent proteins into the secretory pathway, but their role extends far beyond protein targeting.
Maciej Karbownik, Marcin Fidura, Renata Perlikowska   +2 more
doaj   +1 more source

Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA

Cell Reports, 2015
We present the crystal structure of the junction-resolving enzyme GEN1 bound to DNA at 2.5 Å resolution. The structure of the GEN1 protein reveals it to have an elaborated FEN-XPG family fold that is modified for its role in four-way junction resolution.
Yijin Liu, Alasdair D.J. Freeman, Anne-Cécile Déclais, Timothy J. Wilson, Anton Gartner, David M.J. Lilley   +5 more
doaj   +1 more source