Results 151 to 160 of about 202,030 (205)

Calculations of nucleic acid conformations

Current Opinion in Structural Biology, 1996
The present computational power and sophistication of theoretical approaches to nucleic acid structural investigation are sufficient for the realization of static and dynamic models that correlate accurately with current crystallographic, NMR and solution-probing structural data, and consequently are able to provide valuable insights and predictions ...
Auffinger, Pascal, Louise-May, Shirley, Westhof, Eric   +2 more
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Conformations of double-helical nucleic acids

Nature, 1976
A KNOWLEDGE of possible conformational states of double-helical nucleic acids is fundamental to an understanding of how they work1,2. Models for a series of conformations have been made on the basis of X-ray data3–5. Investigations of nucleic acids in solution point to the existence of a continuum of forms but do not make possible the quantitative ...
V E, Khutorsky, V I, Poltev
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The conformations of locked nucleic acids (LNA)

Journal of Molecular Recognition, 2000
We have used 2D NMR spectroscopy to study the sugar conformations of oligonucleotides containing a conformationally restricted nucleotide (LNA) with a 2'-O, 4'-C-methylene bridge. We have investigated a modified 9-mer single stranded oligonucleotide as well as three 9- and 10-mer modified oligonucleotides hybridized to unmodified DNA.
Petersen, Michael B., Nielsen, Christina B., Nielsen, Katrine E., Jensen, Gitte A., Bondensgaard, Kent, Singh, Sanjay Kumar, Rajwanshi, Vivek Kumar, Koshkin, Alexei, Dahl, Britta Mynster, Wengel, Jesper Thagaard, Jacobsen, Jens Peter   +10 more
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Exploring the conformations of nucleic acids

Journal of Functional Programming, 1995
AbstractThis paper presents an application of functional programming in the field of molecular biology: exploring the conformations of nucleic acids. TheNucleic Acid three-dimensional structure determination problem(NA3D) and a constraint satisfaction algorithm are formally described.
Marcel Turcotte, Guy Lapalme, François Major   +2 more
openaire   +1 more source

Conformational Flexibility of Nucleic Acids

1983
In consideration of the importance of conformational flexibility to the functioning of nucleic acids, NMR studies have been carried out to elucidate aspects of dynamics with molecular Mechanics calculations providing supplementary insight. Analysis of 31P and 13C NMR relaxation data in terms of plausible motions in a DNA helix indicate that winding and
Thomas L. James, Peter Bendel, Jacqueline L. James, Joe W. Keepers, Peter A. Kollman, Aviva Lapidot, Joseph Murphy-Boesch, John E. Taylor   +7 more
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Single molecule approaches of nucleic acids conformational changes

Methods, 2019
Single molecule approaches of nucleic acids conformational changes One of the primordial questions today in biology is: how does DNA regulate its own metabolism? In other words, what are the mechanisms that enables specific genes to be transcribed while others are silenced?
Lavelle, Christophe, Tardin, Catherine
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Two contiguous conformations in a nucleic acid duplex

Nature, 1978
DNA CONFORMATIONS and properties depend on DNA sequence and on environmental conditions1–3. It has been suggested that specific regulatory sites on DNA might have unique secondary conformations2. Conformational transitions, and the propagation of these transitions along a DNA helix, have been proposed as mechanistic steps in RNA transcription4 and DNA ...
E, Selsing, R D, Wells, T A, Early, D R, Kearns   +3 more
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Copper(II)-Nucleic acid interactions—A conformational study

Journal of Theoretical Biology, 1979
Abstract The effect of copper complexation upon the conformational angles in mononucleotides and dinucleotides was studied using classical potential energy expressions. The geometrical parameters were taken from crystallographic reports on the base-metal complexes.
J, Bandekar, B K, Sathyanarayana
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Forces involved in the Conformational Stability of Nucleic Acids

Nature, 1969
ONE of the most important problems in research on nucleic acid is the understanding of the forces which maintain the helical structure. After the elucidation of the double helix by Watson and Crick1, the helical secondary structure of DNA was thought to derive its stability from hydrogen bonding between the base pair. The discovery that polynucleotides
J C, Maurizot, J, Brahms, F, Eckstein
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