Results 161 to 170 of about 451,143 (385)
Advanced Healthcare Materials, EarlyView.Polymer‐based drug delivery systems can effectively overcome the limitations of free drugs in terms of solubility, stability, and plasma half‐life, yet their development has traditionally relied on time‐consuming trial‐and‐error approaches. This review highlights recent advances in applying molecular simulation to the design of polymer‐based drug ...
Ping Gao +4 more
wiley +1 more source
Cyclohexenyl nucleic acids: conformationally flexible oligonucleotides [PDF]
, 2005 Koen Nauwelaerts
openalex +1 more source
Nucleic Acid Conformational Penalties from Optical Melting Experiments [PDF]
, 2021 Atul Rangadurai +4 more
openalex +1 more source
Global Studies of Single-Stranded Nucleic Acid Conformation
, 2013 Julie L. Sutton +3 more
semanticscholar +1 more source
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, EarlyView.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
The structural basis of differential DNA sequence recognition by restriction–modification controller proteins [PDF]
, 2012 Ball, Neil J. +4 more
core +1 more source
Drug-nucleic acid interactions: conformational flexibility at the intercalation site.
, 1978 Helen M. Berman +2 more
openalex +2 more sources
Use of the Z-DNA binding domain of ADAR1 as a probe for nucleic acids in left-handed conformation [PDF]
, 2008 Heng Li
openalex +1 more source
Advanced Healthcare Materials, EarlyView.HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu +21 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu +4 more
wiley +1 more source