Direct SERS Detection of Nucleic Acids in the Presence of Spermine: A Unified Nanoparticle Platform Allows for the Elucidation of Surface Adsorption Hierarchies. [PDF]
J Phys Chem C Nanomater InterfacesDeriu C, Fabris L.
europepmc +1 more source
Advanced Science, EarlyView.The research team integrated a potentiometrically controlled pH electrode with carbon nanotube (CNT) field‐effect transistor (FET) biosensors on a single chip using compatible processes. By employing zonal modification and optimized pH‐sensitive probes, they achieved simultaneous quadruple‐target detection and tenfold reusability under physiological ...
Bo Xiao +6 more
wiley +1 more source
New acridone derivatives to target telomerase and oncogenes - an anticancer approach. [PDF]
RSC Med ChemMarques TJS +7 more
europepmc +1 more source
The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source
Synthesis and structural analysis of dinucleotides containing 2',3'-trans-bridged nucleic acids with trans-5,6- or 5,7-fused ring skeleton. [PDF]
Commun ChemOsawa T +4 more
europepmc +1 more source
Advanced Science, EarlyView.DNA‐Based Genetic and Non‐Genetic Tools for Receptor Engineering. This review highlights recent advances in DNA‐based strategies for receptor engineering, including genetic approaches like domain fusion and site‐directed mutagenesis, as well as non‐genetic methods using functional nucleic acids, DNA nanostructures, and dynamic DNA reactions.
Hexin Nan +4 more
wiley +1 more source
Conserved long-range interactions are required for stable folding of orthoflaviviral genomic RNA. [PDF]
Nucleic Acids ResPalo MZ +7 more
europepmc +1 more source
The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling
Advanced Science, EarlyView.The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu +17 more
wiley +1 more source
Caught in the Middle: A Rigid DNA Label That Provides an Incisive Picture of DNA Conformational Flexibility in Protein-DNA Complexes. [PDF]
J Am Chem SocCasto J +5 more
europepmc +1 more source
Advanced Science, EarlyView.Pulmonary fibrosis (PF) is promoted by NETs that induce fibroblast activation. PEG‐PIm, a polymeric artificial DNase is reported that efficiently degrades NET‐DNA via phosphodiester bond hydrolysis. Inhalation of PEG‐PIm in a mouse PF model prevents fibroblast activation and fibrosis progression, offering a promising therapeutic strategy for NET ...
Yibo Du +7 more
wiley +1 more source