Results 291 to 300 of about 438,619 (385)

Molecular Tweezers for Biomimetic Recognition of Carbohydrates. [PDF]

Chembiochem
Milanesi F, Mohamedzakaria Shibinasbarveen N, Roelens S, Francesconi O.   +3 more
europepmc   +1 more source

BRD4 Signaling Maintains the Differentiated State of β Cells

Advanced Science, EarlyView.
The comprehensive exploration revealed the critical role of BRD4 in β cells. BRD4 plays a fundamental role in maintaining β cell differentiation because both long‐term and acute BRD4 deficiency result in a reduction in insulin secretion and downregulation of differentiation markers.
Fuqiang Liu, Guang Liu, Jia Song, Yujing Sun, Mengmeng Yang, Hualin Liu, Hongkai Zhao, Jiamu Chen, Qincheng Qiao, Siyue Li, Chenglong Yu, Jingru Qu, Ying Zou, Tixiao Wang, Jidong Liu, Lei Zhao, Huihui Tian, Tao Huang, Manna Zhang, Li Chen, Ruxing Zhao, Yuanyuan Du, Xinguo Hou   +22 more
wiley   +1 more source

Structural and functional studies of the main replication protein NS1 of human parvovirus B19. [PDF]

Nucleic Acids Res
Zhang Y, Fan B, Gao Y, Yang J, Zhang W, Su S, Li L, Li H, Luo Z, Tang G, Wang C, Zhang X, Liu H, Gan J.   +13 more
europepmc   +1 more source

DNA Sequential Logic Circuits for Reversible Counters and Dynamic Biomolecular Sensing

Advanced Science, EarlyView.
In this work, a DNA sequential logic circuit is constructed that combines reusability and autonomy for the first time, including SR (Set‐Reset)‐latches composed of NOR gates, SR‐latches composed of NAND gates, and D (Data)‐latches. After fully utilizing the characteristics of each latch, to counter, toxin and miRNA detection and intracellular dynamic ...
Tianci Xie, Changjiang Li, Minghao Hu, Xingyu Zhong, Junbin Xiao, Zhen Zhang, Ze Wang, Tongbo Wu   +7 more
wiley   +1 more source

Melting Profile of DNA in Crowded Solution: Model-Based Study. [PDF]

Int J Mol Sci
Mathur N, Singh A, Singh N.
europepmc   +1 more source

Single‐Droplet Dual‐Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening

Advanced Science, EarlyView.
Circular RNAs are crucial in tumorigenesis. This study identifies circCK1γ3 and circWDR37 as dual plasma biomarkers for colorectal cancer (CRC) screening. It is developed Casµchip, a droplet microfluidic chip using Cas13a/b technology to quantify these biomarkers.
Jingsong Xu, Yu Liu, Junheng Zhang, Shuang Yang, Tianming Li, Haiqian Huang, Qian Liu, Hengliang Wang, Li Cao, Zhenghua An, Min Li, Hua Wang   +11 more
wiley   +1 more source

Alphaflexiviridae in Focus: Genomic Signatures, Conserved Elements and Viral-Driven Cellular Remodeling. [PDF]

Viruses
Úbeda JR, Aranda MA, Donaire L.
europepmc   +1 more source

A Phase Separation‐Assisted Pre‐Enrichment Method for Ultrasensitive Respiratory Virus Detection

Advanced Science, EarlyView.
Conventional biomarker enrichment lacks versatility and specificity. Phase separation‐assisted pre‐enrichment (PSAP) is introduced for concurrent antigen (47×) and RNA (44×) enrichment. Tenfold and fivefold lower detection limits for SARS‐CoV‐2 and Influenza, respectively, were achieved.
Yang Cao, Pui Ngan Lau, Alex W.H. Chin, Zhuolin He, Christina C. K. Au Yeung, Kehao Zeng, Haisong Lin, Leo L. M. Poon, Ho Cheung Shum   +8 more
wiley   +1 more source

Advancing Design Strategy of PROTACs for Cancer Therapy. [PDF]

MedComm (2020)
Luo H, Tian Y, Abdullah R, Zhang B, Ma Y, Zhang G.   +5 more
europepmc   +1 more source

Development of a DNA Aptamer‐Based Approach to Noninvasively Image CAR‐T Cells In Vivo and Traceless Enrichment In Vitro

Advanced Science, EarlyView.
A DNA aptamer (A3) with nanomolar affinity for CAR‐T cells is developed via Cell‐SELEX. In Nalm6 tumor‐bearing mice, Cy5‐labeled A3 enables long‐term fluorescence imaging and tracks the biodistribution of CAR‐T cells, with tumor signal peaking on day 14 after CAR‐T cell administration.
Minghui Chen, Pengzhao Chang, Zhen Zhang, Dan Liu, Rui Hou, Ming Shi, Jingjing Li, Kai Xu, Junnian Zheng   +8 more
wiley   +1 more source