Results 291 to 300 of about 451,143 (385)

Isoorotamide-based peptide nucleic acid nucleobases with extended linkers aimed at distal base recognition of adenosine in double helical RNA. [PDF]

Beilstein J Org Chem
Walby GD, Tessier BR, Mabee TL, Hoke JM, Bleam HM, Giglio-Tos A, Harding EE, Baskevics V, Katkevics M, Rozners E, MacKay JA.   +10 more
europepmc   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Cas12a-assisted split crRNA complex for analysis and detection of diverse entities. [PDF]

Nucleic Acids Res
Xiao Y, Zhao R, Bao Y, Lu B, Jiang Y, Tang Y, Li B.   +6 more
europepmc   +1 more source

Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression

Advanced Science, EarlyView.
Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li, Pushpa Dhilipkannah, Van K Holden, Ashutosh Sachdeva, Feng Jiang   +4 more
wiley   +1 more source

Exploring the temperature stability of CRISPR-Cas12b using molecular dynamics simulations.

Mol Syst Des Eng
Jia Y, Horvath K, Rananaware SR, Jain PK, Sampath J.   +4 more
europepmc   +1 more source

Electromagnetic Field Stimulation Effects on Intrinsically Disordered Proteins and Their Role in Aging and Neurodegeneration. [PDF]

J Biomed Sci Eng
Perez FP, Bandeira J, Morisaki J, Kanakri H, Rizkalla M.   +4 more
europepmc   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Structural flexibility in the ordered domain of the dengue virus strain 2 capsid protein is critical for chaperoning viral RNA replication. [PDF]

Cell Mol Life Sci
Sharma KK, Raghuvamsi PV, Aik DYK, Marzinek JK, Bond PJ, Wohland T.   +5 more
europepmc   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source