Photonics, 2023 This review deals with modern approaches to systematic research on molecular-kinetic mechanisms of damage recognition and removal by pro- and eukaryotic enzymes of DNA base excision repair.
Nikita A. Kuznetsov
doaj +1 more source
Structural and mutagenic analysis of the RM controller protein C.Esp1396I [PDF]
, 2014 Bacterial restriction-modification (RM) systems are comprised of two complementary enzymatic activities that prevent the establishment of foreign DNA in a bacterial cell: DNA methylation and DNA restriction.
Kneale, Geoff +2 more
core +3 more sources
The development of biomolecular Raman optical activity spectroscopy [PDF]
, 2015 Following its first observation over 40 years ago, Raman optical activity (ROA), which may be measured as a small difference in the intensity of vibrational Raman scattering from chiral molecules in right- and left-circularly polarized incident light or,
Barron, Laurence D.
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A Chimeric DNA/RNA Antiparallel Quadruplex with Improved Stability
ChemistryOpen, 2022 Nucleic acid quadruplexes are proposed to play a role in the regulation of gene expression, are often present in aptamers selected for specific binding functions and have potential applications in medicine and biotechnology.
Elaina P. Boyle +3 more
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Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. [PDF]
, 2016 RNA polymerase II (pol II) utilizes a complex interaction network to select and incorporate correct nucleoside triphosphate (NTP) substrates with high efficiency and fidelity.
Chong, Jenny +10 more
core +2 more sources
Atypical response regulator ChxR from Chlamydia trachomatis is structurally poised for DNA binding. [PDF]
PLoS ONE, 2014 ChxR is an atypical two-component signal transduction response regulator (RR) of the OmpR/PhoB subfamily encoded by the obligate intracellular bacterial pathogen Chlamydia trachomatis. Despite structural homology within both receiver and effector domains
Michael L Barta +5 more
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Original Synthesis of a Nucleolipid for Preparation of Vesicular Spherical Nucleic Acids
Nanomaterials, 2022 Spherical nucleic acids (SNAs)—nanostructures, consisting of a nanoparticle core densely functionalized with a shell of short oligonucleotide strands—are a rapidly emerging class of nanoparticle-based therapeutics with unique properties and specific ...
Erik Dimitrov +8 more
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Ion-mediated RNA structural collapse: effect of spatial confinement [PDF]
, 2012 RNAs are negatively charged molecules residing in macromolecular crowding cellular environments. Macromolecular confinement can influence the ion effects in RNA folding.
Chen, Shi-Jie, Tan, Zhi-Jie
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Conformation of nucleic acids and the analysis of the hypochromic effect [PDF]
Biochemical Journal, 1970 The spectra of two double-helical RNA species isolated from virus-like particles found in the mycelium of Penicillium chrysogenum were measured at about 25 degrees C, and at 95 degrees C after denaturation to a single-stranded form, and compared with the spectrum of the equivalent mixture of nucleotides.
openaire +3 more sources
RosettaBackrub--a web server for flexible backbone protein structure modeling and design. [PDF]
, 2010 The RosettaBackrub server (http://kortemmelab.ucsf.edu/backrub) implements the Backrub method, derived from observations of alternative conformations in high-resolution protein crystal structures, for flexible backbone protein modeling.
Friedland, Gregory F +4 more
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