Results 81 to 90 of about 470,550 (372)

Identification of the Myogenetic Oligodeoxynucleotides (myoDNs) That Promote Differentiation of Skeletal Muscle Myoblasts by Targeting Nucleolin

Frontiers in Cell and Developmental Biology, 2021
Herein we report that the 18-base telomeric oligodeoxynucleotides (ODNs) designed from the Lactobacillus rhamnosus GG genome promote differentiation of skeletal muscle myoblasts which are myogenic precursor cells. We termed these myogenetic ODNs (myoDNs).
Sayaka Shinji, Koji Umezawa, Koji Umezawa, Yuma Nihashi, Shunichi Nakamura, Takeshi Shimosato, Takeshi Shimosato, Takeshi Shimosato, Takeshi Shimosato, Tomohide Takaya, Tomohide Takaya, Tomohide Takaya, Tomohide Takaya   +12 more
doaj   +1 more source

Unraveling the metastasis‐preventing effect of miR‐200c in vitro and in vivo

Molecular Oncology, EarlyView.
Advanced tumors and ineffective cancer treatments can lead to metastases in distant organs. The sole expression of microRNA 200c (miR‐200c) in breast cancer cells is shown to significantly reduce metastasis formation in xenograft mouse models. Various in vitro analyses revealed impeded migratory behavior, upon miR‐200c expression, as one prerequisite ...
Bianca Köhler, Emily Brieger, Tom Brandstätter, Elisa Hörterer, Ulrich Wilk, Jana Pöhmerer, Anna Jötten, Philipp Paulitschke, Chase P. Broedersz, Stefan Zahler, Joachim O. Rädler, Ernst Wagner, Andreas Roidl   +12 more
wiley   +1 more source

Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.

Journal of the American Chemical Society, 2017
Here we report the investigation of glycol nucleic acid (GNA), an acyclic nucleic acid analogue, as a modification of siRNA duplexes. We evaluated the impact of (S)- or (R)-GNA nucleotide incorporation on RNA duplex structure by determining three ...
M. Schlegel, Donald J. Foster, A. Kel'in, Ivan Zlatev, Anna Bisbe, M. Jayaraman, J. Lackey, K. G. Rajeev, K. Charissé, J. Harp, P. Pallan, M. Maier, M. Egli, M. Manoharan   +13 more
semanticscholar   +1 more source

Electrostatics of Nucleic Acid Folding under Conformational Constraint [PDF]

Journal of the American Chemical Society, 2012
RNA folding is enabled by interactions between the nucleic acid and its ion atmosphere, the mobile sheath of aqueous ions that surrounds and stabilizes it. Understanding the ion atmosphere requires the interplay of experiment and theory. However, even an apparently simple experiment to probe the ion atmosphere, measuring the dependence of DNA duplex ...
Vincent B. Chu, Peter C. Anthony, Steven M. Block, Daniel Herschlag, Sebastian Doniach, Adelene Y. L. Sim   +5 more
openaire   +3 more sources

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

Pyrrolidine nucleotide analogs with a tunable conformation

Beilstein Journal of Organic Chemistry, 2014
Conformational preferences of the pyrrolidine ring in nucleotide analogs 7–14 were investigated by means of NMR and molecular modeling. The effect of the relative configuration of hydroxy and nucleobase substituents as well as the effect of the ...
Lenka Poštová Slavětínská, Dominik Rejman, Radek Pohl   +2 more
doaj   +1 more source

Human Norovirus Aptamer Exhibits High Degree of Target Conformation-Dependent Binding Similar to That of Receptors and Discriminates Particle Functionality

mSphere, 2016
Although two in vitro cultivation methods have been reported, discrimination of infectious human norovirus particles for study of viral inactivation is still a challenge, as both rely on reverse transcriptase quantitative PCR.
Matthew D. Moore, Benjamin G. Bobay, Brittany Mertens, Lee-Ann Jaykus   +3 more
doaj   +1 more source

Structural properties of the linkers connecting the n- and c- terminal domains in the mocr bacterial transcriptional regulators [PDF]

, 2016
Peptide inter-domain linkers are peptide segments covalently linking two adjacent domains within a protein. Linkers play a variety of structural and functional roles in naturally occurring proteins.
ANGELACCIO, Sebastiana, CONTESTABILE, Roberto, DI SALVO, Martino Luigi, MILANO, TERESA, PASCARELLA, Stefano, TRAMONTI, Angela   +5 more
core   +3 more sources

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources

Single-stranded nucleic acid elasticity arises from internal electrostatic tension

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Charged, flexible polymers, such as single-stranded nucleic acids (ssNAs), are ubiquitous in biology and technology. Quantitative description of their solution conformation has remained elusive due to the competing effects of polymer ...
David R. Jacobson, D. B. McIntosh, M. Stevens, M. Rubinstein, O. Saleh   +4 more
semanticscholar   +1 more source