Results 81 to 90 of about 202,030 (205)

Sensing the structural and conformational properties of single-stranded nucleic acids using electrometry and molecular simulations

Scientific Reports
Inferring the 3D structure and conformation of disordered biomolecules, e.g., single stranded nucleic acids (ssNAs), remains challenging due to their conformational heterogeneity in solution.
Rowan Walker-Gibbons, Xin Zhu, Ali Behjatian, Timothy J. D. Bennett, Madhavi Krishnan   +4 more
doaj   +1 more source

MD SIMULATION STUDIES TO INVESTIGATE ISO-ENERGETIC CONFORMATIONAL BEHAVIOUR OF MODIFIED NUCLEOSIDES M2G AND M22G PRESENT IN tRNA

Computational and Structural Biotechnology Journal, 2013
Modified nucleic acid bases are most commonly found in tRNA. These may contain modifications from simple methylation to addition of bulky groups. Methylation of the four canonical nucleotide bases at a wide variety of positions is particularly prominent ...
Rohit S Bavi, Susmit B Sambhare, Kailas D Sonawane   +2 more
doaj   +1 more source

Structure motivator: a tool for exploring small three-dimensional elements in proteins [PDF]

, 2012
<br>Background: Protein structures incorporate characteristic three-dimensional elements defined by some or all of hydrogen bonding, dihedral angles and amino acid sequence.
Leader, D.P., Milner-White, E.J.
core   +3 more sources

Single-Molecule Analysis of i-motif Within Self-Assembled DNA Duplexes and Nanocircles [PDF]

, 2019
The cytosine (C)-rich sequences that can fold into tetraplex structures known as i-motif are prevalent in genomic DNA. Recent studies of i-motif–forming sequences have shown increasing evidence of their roles in gene regulation.
Cox, Bobby D., Dhakal, Soma, Kaur, Anisa, Megalathan, Anoja, Reiner, Joseph E., Sapkota, Kumar, Wilkerson, Peter D.   +6 more
core   +1 more source

Halogen Bonding in Nucleic Acid Complexes

, 2017
Halogen bonding (X-bonding) has attracted notable attention among noncovalent interactions. This highly directional attraction between a halogen atom and an electron donor has been exploited in knowledge-based drug design. A great deal of information has
Kolář, Michal H., Tabarrini, Oriana
core   +1 more source

Development of the 12-Base Short Dimeric Myogenetic Oligodeoxynucleotide That Induces Myogenic Differentiation

BioTech
A myogenetic oligodeoxynucleotide (myoDN), iSN04 (5′-AGA TTA GGG TGA GGG TGA-3′), is a single-stranded 18-base telomeric DNA that serves as an anti-nucleolin aptamer and induces myogenic differentiation, which is expected to be a nucleic acid drug for ...
Koji Umezawa, Rena Ikeda, Taiichi Sakamoto, Yuya Enomoto, Yuma Nihashi, Sayaka Shinji, Takeshi Shimosato, Hiroshi Kagami, Tomohide Takaya   +8 more
doaj   +1 more source

Rapid In-Vitro Inactivation of Various SARS-CoV-2 Strains Using Ionizing Radiation: New Inactivation Patterns and Mechanistic Insights

Engineering
Ionizing radiation presents an important solution for virus inactivation. However, its efficacy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivation and the underlying mechanisms remain unclear.
Wei Wang, Xiaodi Zhang, Jiageng Yu, Tianhao Weng, Zhiyang Yu, Zhigang Wu, Danrong Shi, Sufen Zhang, Xiangyun Lu, Osama Alam, Dahang Shen, Qian Bao, Qingfu Ye, Lanjuan Li, Hangping Yao   +14 more
doaj   +1 more source

An epimer of threose nucleic acid enhances oligonucleotide exonuclease resistance through end capping

Communications Chemistry
End capping of oligonucleotides by modified nucleotides is essential for boosting resistance to 3’ exonuclease degradation, thereby enhancing their stability and therapeutic efficacy in vivo.
Junlin Wen, Chunlei Zhang, Xue Chen, Ziwen Dai, Mengting Li, Wenjian Ma, ChiYung Yam, Xiaoluo Huang, Chenghe Xiong, Hui Mei   +9 more
doaj   +1 more source

pH-Control in Aptamer-Based Diagnostics, Therapeutics, and Analytical Applications

Pharmaceuticals, 2018
Aptamer binding has been used effectively for diagnostics, in-vivo targeting of therapeutics, and the construction and control of nanomachines. Nanostructures that respond to pH by releasing or changing affinity to a target have also been used for in ...
Micaela Belleperche, Maria C. DeRosa
doaj   +1 more source

Free-energy simulations reveal molecular mechanism for functional switch of a DNA helicase

eLife, 2018
Helicases play key roles in genome maintenance, yet it remains elusive how these enzymes change conformations and how transitions between different conformational states regulate nucleic acid reshaping.
Wen Ma, Kevin D Whitley, Yann R Chemla, Zaida Luthey-Schulten, Klaus Schulten   +4 more
doaj   +1 more source