Results 231 to 240 of about 5,943,194 (262)

Density and structure of DNA immobilised on gold nanoparticles affect sensitivity in nucleic acid detection. [PDF]

Sci Rep
Fukuzumi N, Hirao G, Ogawa A, Asahi T, Maeda M, Zako T.   +5 more
europepmc   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Development of a rapid on-site nucleic acid detection method for new genotype muscovy duck parvovirus based on RPA-CRISPR/Cas12a. [PDF]

Front Vet Sci
Liang Q, Chen W, Wang W, Liu R, Fu Q, Fu G, Cheng L, Jiang N, Chen H, Huang Y.   +9 more
europepmc   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Deep Learning-Enhanced Hand-Driven Microfluidic Chip for Multiplexed Nucleic Acid Detection Based on RPA/CRISPR. [PDF]

Adv Sci (Weinh)
Xu T, Zhang Y, Li S, Dai C, Wei H, Chen D, Zhao Y, Liu H, Li D, Chen P, Liu BF, Tian Y.   +11 more
europepmc   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Sandwich-type graphene electrochemical sensor for nucleic acid detection of SARS-CoV-2. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Yang H, Li Y, Cao D, He L, Guo Y, Liu Z, Zhang H.   +6 more
europepmc   +1 more source

Tunable control of Cas12 activity promotes universal and fast one-pot nucleic acid detection. [PDF]

Nat Commun
Cheng ZH, Luo XY, Yu SS, Min D, Zhang SX, Li XF, Chen JJ, Liu DF, Yu HQ.   +8 more
europepmc   +1 more source

Innovative nucleic acid detection of <i>Clostridioides difficile</i> utilizing the PAM-unconventional, one-step LAMP/CRISPR-Cas12b detection platforms. [PDF]

Front Cell Infect Microbiol
Zhang Y, Lv L, Xu S, Chen Y.
europepmc   +1 more source

Study on the correlation between abdominal infection and psychological stress in children based on nucleic acid detection. [PDF]

World J Psychiatry
Wang GB, Zhang XF, Liang B, Lei J, Xue J.   +4 more
europepmc   +1 more source