Results 241 to 250 of about 316,767 (328)

i-Motif DNA molecular beacon for microRNA detection. [PDF]

open access: yesNucleic Acids Res
Luo T   +5 more
europepmc   +1 more source

Single‐Molecule Protein Profiling Using Nanopores and Dimeric Aptamer‐Modified DNA Carriers

open access: yesAngewandte Chemie, EarlyView.
We developed a nanopore‐based biosensor for single‐molecule protein profiling using aptamer‐modified DNA carrier dimerization strategy, enabling selective and ultrasensitive detection of proteins and protein complexes. This approach promises advances in early‐stage clinical diagnostics and precision medicine.
Xiaoyi Wang   +4 more
wiley   +1 more source

Synthesis of Versatile DNA‐Conjugated Aldehydes by Controlled Oxidation of Amines

open access: yesAngewandte Chemie, EarlyView.
A controlled oxidation strategy enables efficient in situ generation of aldehyde‐functionalized DNAs from DNA‐conjugated amines using O2/laccase/TEMPO. This approach facilitates reversible amine–aldehyde transformations for DNA bioconjugation, and provides access to chemically diverse DNA‐encoded libraries, broadening the toolbox for chemical biology ...
Guixian Zhao   +6 more
wiley   +1 more source

Rapid Amplification and Detection of Single-Stranded Nucleic Acids for Point-of-Care Diagnosis. [PDF]

open access: yesSmall Methods
Fu J   +6 more
europepmc   +1 more source

Enhancing Clinical Detection Accuracy of Large Structured Viral RNA via DNAzyme Cleavage and Antisense‐Assisted Rolling Circle Amplification

open access: yesAngewandte Chemie, EarlyView.
We show that antisense oligonucleotides can be used to restructure secondary structural elements around the circular DNA template binding sites of the genomic RNA for subsequent rolling circle amplification. This strategy was employed to identify otherwise COVID “false negative” saliva samples by accurately detecting the presence of SARS‐CoV‐2 genomic ...
Amal Mathai   +4 more
wiley   +1 more source

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