Photoinitiator Nucleotide for Quantifying Nucleic Acid Hybridization [PDF]
Biomacromolecules, 2010 This first report of a photoinitiator-nucleotide conjugate demonstrates a novel approach for sensitive, rapid and visual detection of DNA hybridization events. This approach holds potential for various DNA labeling schemes and for applications benefiting from selective DNA-based polymerization initiators.
Robert D. Kuchta +4 more
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Nucleic acid - protein fingerprints. Novel protein classification based on nucleic acid - protein recognition [PDF]
, 2012 Protein chemistry uses protein description and classification based on molecular mass and isoelectric point as general features. Enzymes are also compared by enzymatic reaction constants, namely Km and kcat values. Proteins are also studied by binding to
Alexander Krylov, Renad Zhdanov
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A novel cassette method for probe evaluation in the designed biochips [PDF]
, 2014 A critical step in biochip design is the selection of probes with identical hybridisation characteristics. In this article we describe a novel method for evaluating DNA hybridisation probes, allowing the fine-tuning of biochips, that uses cassettes with ...
Al-humam, Abdulmohsen A. +7 more
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, 2011 Loops are essential secondary structure elements in folded DNA and RNA molecules and proliferate close to the melting transition. Using a theory for nucleic acid secondary structures that accounts for the logarithmic entropy c ln m for a loop of length m,
Einert, Thomas R. +2 more
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Nucleic acids and protein synthesis in cancer cell mitochondria. I. Nucleic acids in rat hepatoma mitochondria [PDF]
, 1967 The contents of nucleic acids in rat liver and hepatoma mitochondria and the physico-chemical properties on DNA's isolated from these mitochondria were comparatively investigated. The results are briefly summarized as follows. 1.
Inaba, Kozo
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A cellulose-based bioassay for the colorimetric detection of pathogen DNA [PDF]
, 2014 Cellulose-paper-based colorimetric bioassays may be used at the point of sampling without sophisticated equipment. This study reports the development of a colorimetric bioassay based on cellulose that can detect pathogen DNA.
Goyal, Madhu +3 more
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Evaluation of Microfluidic Biosensor Development Using Microscopic Analysis of Molecular Beacon Hybridization [PDF]
. Molecular beacons, oligonucleotide probes that fluoresce upon hybridization to a target nucleic acid, can be used in microfluidic devices to detect and quantify nucleic acids in solution as well as inside bacterial cells.
Chuanwu Xi, Lutgarde Raskin
core
From aptamer-based biomarker discovery to diagnostic and clinical applications: an aptamer-based, streamlined multiplex proteomic assay [PDF]
, 2010 Recently, we reported an aptamer-based, highly multiplexed assay for the purpose of biomarker identification. To enable seamless transition from highly multiplexed biomarker discovery assays to a format suitable and convenient for diagnostic and life ...
Christopher Bock +10 more
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A Family of Developmentally Excised DNA Elements in \u3cem\u3eTetrahymena\u3c/em\u3e is under Selective Pressure to Maintain an Open Reading Frame Encoding an Integrase-Like Protein [PDF]
, 2000 Tlr1 is a member of a family of ~20-30 DNA elements that undergo developmentally regulated excision during formation of the macronucleus in the ciliated protozoan Tetrahymena.
Gershan, Jill A., Karrer, Kathleen M.
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Towards combining backbone and sugar constraint in 3-3 bis-phosphonate tethered 2-4 bridged LNA oligonucleotide trimers. [PDF]
Therapeutic oligonucleotides are chemically modified to enhance their drug-like properties - including binding affinity for target RNA. Many nucleic acid analogs that enhance RNA binding affinity constrain the furanose sugar in an RNA-like sugar pucker ...
Duchamp, Edouard +6 more
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