Dual Resonance Energy Transfer Nucleic Acid Probes [PDF]
Dual nucleic acid probes with resonance energy transfer moieties are provided. In particular, fluorescent or luminescent resonance energy transfer moieties are provided on hairpin stem-loop molecular beacon probes that hybridize sufficiently near each ...
core
Flexibility-Rigidity Index for Protein-Nucleic Acid Flexibility and Fluctuation Analysis [PDF]
arXiv, 2015 Protein-nucleic acid complexes are important for many cellular processes including the most essential function such as transcription and translation. For many protein-nucleic acid complexes, flexibility of both macromolecules has been shown to be critical for specificity and/or function. Flexibility-rigidity index (FRI) has been proposed as an accurate
arxiv
Recent developments in the characterization of nucleic acid hybridization kinetics. [PDF]
Curr Opin Biomed Eng, 2021 Chen YI +6 more
europepmc +1 more source
A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions. [PDF]
Nat Commun, 2021 Liu B +8 more
europepmc +1 more source
Nucleic acid - protein fingerprints. Novel protein classification based on nucleic acid - protein recognition [PDF]
, 2012 Protein chemistry uses protein description and classification based on molecular mass and isoelectric point as general features. Enzymes are also compared by enzymatic reaction constants, namely Km and kcat values. Proteins are also studied by binding to
Alexander Krylov, Renad Zhdanov
core +1 more source
A tripartile biosensor for real-time SNSs detection in DNA hairpin motif [PDF]
, 2011 The hybridization between two complementary strands of nucleic acid is the basis for a number of applications in DNA and RNA analysis, including in vivo RNA monitoring, microarrays, SNPs detection, and so on.
Nguyen, Camha
core +1 more source
Lateral flow microarrays: a novel platform for rapid nucleic acid detection based on miniaturized lateral flow chromatography [PDF]
Widely used nucleic acid assays are poorly suited for field deployment where access to laboratory instrumentation is limited or unavailable. The need for field deployable nucleic acid detection demands inexpensive, facile systems without sacrificing ...
Carter, Darren J., Cary, R. Bruce
core +2 more sources
Evaluation of Microfluidic Biosensor Development Using Microscopic Analysis of Molecular Beacon Hybridization [PDF]
. Molecular beacons, oligonucleotide probes that fluoresce upon hybridization to a target nucleic acid, can be used in microfluidic devices to detect and quantify nucleic acids in solution as well as inside bacterial cells.
Chuanwu Xi, Lutgarde Raskin
core
A physicist's view of DNA [PDF]
De Physicus, 24e, 3, 59-61 (2013), 2013 Nucleic acids, like DNA and RNA, are molecules that are present in any life form. Their most notable function is to encode biological information. Why then would a physicist be interested in these molecules? As we will see, DNA is an interesting molecular tool for physicists to test and explore physical laws and theories, like the ergodic theorem, the ...
arxiv
Mechanism of thermal renaturation and hybridization of nucleic acids: Kramers process and universality in Watson-Crick base pairing [PDF]
arXiv, 2008 Renaturation and hybridization reactions lead to the pairing of complementary single-stranded nucleic acids. We present here a theoretical investigation of the mechanism of these reactions in vitro under thermal conditions (dilute solutions of single-stranded chains, in the presence of molar concentrations of monovalent salts and at elevated ...
arxiv