Results 221 to 230 of about 48,779 (251)

The Role of the Membrane in the Utilization of Nucleic Acid Precursor

CRC Critical Reviews in Biochemistry, 1974
(1974). The Role of the Membrane in the Utilization of Nucleic Acid Precursor. CRC Critical Reviews in Biochemistry: Vol. 2, No. 2, pp. 259-310.
B. Magasanik, Joy Hochstadt
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Uptakein Vitro of nucleic acid precursors and nucleic acids by Zajdela ascitic hepatoma cells

The Journal of Membrane Biology, 1975
Zajdela ascitic hepatoma cells are shown to take up pyrimidine bases at much lower rates than obtained in slices from normal rat liver. The rates of uptake of adenine and uridine by the Zajdela cells are, however, as high as in the slices. Like the slices, again, the Zajdela cells take up E.
D. Szafarz, C. A. Bornecque, F. Zajdela, P. M. Bhargava   +3 more
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Metabolism of caffeine to nucleic acid precursors in mammalian cells

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1976
Caffeine is rapidly metabolized in human and mouse cells in culture by de-methylation: within 1-3 h of exposure to millimolar concentrations of labeled caffeine, more than 90% of the pool consists of labeled products of metabolism and less than 10% is still caffeine. The methyl groups seem to be transferred and used in the de novo synthesis of thymine,
Regine Goth, James E. Cleaver
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Synthesis of phage-precursor nucleic acid in the presence of chloramphenicol

Virology, 1957
If chloramphenicol is added to a bacterial culture infected with T2 some minutes earlier, synthesis of phage nucleic acid proceeds with very little concomitant protein synthesis. If chloramphenicol is subsequently removed, phage particles promptly start to form, and the phosphorus of nucleic acid synthesized during the chloramphenicol period enters ...
N. E. Melechen, Alfred Day Hershey
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Inhibitory effects of orotate on precursor incorporation into nucleic acids

Chemico-Biological Interactions, 1990
The influence of orotic acid on the incorporation of precursors into nucleic acids was studied in mice and rats and in isolated cells. In vivo, orotate levels were modified by two diets which are known to increase the rate of pyrimidine nucleotide synthesis in rat liver.
Albert Assad, Aleykutty Luke, Michael A. Lea, Sudha Ayyala   +3 more
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Peptide Nucleic Acids Targeted to the Amyloid Precursor Protein

Journal of Molecular Neuroscience, 2003
The depositing in brain of amyloid beta peptide (Abeta), which is formed by the cleavage of amyloid precursor protein (APP), is likely an etiologic factor in Alzheimer's disease (AD). Of the different forms of Abeta, Abeta(1-42) causes fibril formation and increases aggregation at elevated levels, which can lead to neuronal death.
Elliott Richelson, Steven G. Younkin, Beth M. McMahon, Abdul H. Fauq, Linda H. Younkin, Jennifer A. Stewart   +5 more
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Adenosylmethionine as a Precursor for Nucleic Acids Modification

1980
Adenosylmethionine (Ado-Met) is the most important donor of alkyl groups, which are transferred from the sulfonium pole to a variety of nucleophilic molecular species within the cell1. The reaction involves nucleophilic attack to one of the three carbon atoms adjacent to the electron-deficient trivalent sulfur (see Figure 1) and is catalyzed by ...
SALVATORE, FRANCESCO, TRABONI, CINZIA, COLONNA, ALFREDO, CILIBERTO, GENNARO, PAOLELLA, GIOVANNI, CIMINO, FILIBERTO   +5 more
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Nucleic acid-like structures II. Polynucleotide analogues as possible primitive precursors of nucleic acids

Origins of life and evolution of the biosphere, 1987
Activated derivatives of purine-containing deoxynucleoside- diphosphates spontaneously oligomerize to produce pyrophosphate- linked oligodeoxynucleotide analogues. These analogues are of potential interest as models of primitive, polynucleotide precursors.
J. Niessen, Alan W. Schwartz, C. G. Bakker, J. Visscher   +3 more
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A Second Pathway to Degrade Pyrimidine Nucleic Acid Precursors in Eukaryotes

Journal of Molecular Biology, 2008
Pyrimidine bases are the central precursors for RNA and DNA, and their intracellular pools are determined by de novo, salvage and catabolic pathways. In eukaryotes, degradation of uracil has been believed to proceed only via the reduction to dihydrouracil.
Michael P. B. Sandrini, Michael P. B. Sandrini, Annamaria Merico, Hans-Erik Åkerlund, Anders Hofer, Thomas Moritz, Yuriy Pynyaha, Jure Piškur, Jure Piškur, Silvia Polakova, Olof Björnberg, Gorm Andersen, Anna Rasmussen, Kasper Møller, Concetta Compagno, Zoran Gojković   +15 more
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