Results 31 to 40 of about 48,779 (251)

Biophysical and Biochemical Characterization of the Binding of the MarR-like Transcriptional Regulator Saro_0803 to the nov1 Promotor and Its Inhibition by Resveratrol

Biomolecules, 2023
Saro_0803 is a transcriptional factor modulating the transcription of the stilbene-degrading enzyme gene nov1 in Novosphingobium aromaticivorans DSM 12444.
Zhen He, Zunhui Ke, Wei Wang, Yahui Liu, Haoran Zhang, Yan Li   +5 more
doaj   +1 more source

A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration.

PLoS Genetics, 2008
Several human neurodegenerative disorders are characterized by the accumulation of 8-oxo-7,8-dihydroguanine (8-oxodG) in the DNA of affected neurons.
Gabriele De Luca, Maria Teresa Russo, Paolo Degan, Cecilia Tiveron, Andrea Zijno, Ettore Meccia, Ilenia Ventura, Elisabetta Mattei, Yusaku Nakabeppu, Marco Crescenzi, Rita Pepponi, Antonella Pèzzola, Patrizia Popoli, Margherita Bignami   +13 more
doaj   +1 more source

Bacteriophage Assembly

Viruses, 2011
Bacteriophages have been a model system to study assembly processes for over half a century. Formation of infectious phage particles involves specific protein-protein and protein-nucleic acid interactions, as well as large conformational changes of ...
Anastasia A. Aksyuk, Michael G. Rossmann
doaj   +1 more source

Translin facilitates RNA polymerase II dissociation and suppresses genome instability during RNase H2- and Dicer-deficiency.

PLoS Genetics, 2022
The conserved nucleic acid binding protein Translin contributes to numerous facets of mammalian biology and genetic diseases. It was first identified as a binder of cancer-associated chromosomal translocation breakpoint junctions leading to the ...
Natalia Gomez-Escobar, Ahad A A Alsaiari, Hanadi A S Alahamadi, Othman Alzahrani, Ellen Vernon, Hussam A E Althagafi, Nasser S Almobadel, David W Pryce, Jane A Wakeman, Ramsay J McFarlane   +9 more
doaj   +1 more source

Synthesis and Regulation of Folate Coenzymes During early Germination in Vigna radiata

Pteridines, 2001
Folate profiles and DNA synthesis were studied during the early germinating period in Vigna radiata. Total folate andmethyl folate forms were increased from 4 to 32 hours during germination period studied.
Kesavan V., Singh N., Pote M.S., Viswanathan G.   +3 more
doaj   +1 more source

Diversity of Endonuclease V: From DNA Repair to RNA Editing

Biomolecules, 2015
Deamination of adenine occurs in DNA, RNA, and their precursors via a hydrolytic reaction and a nitrosative reaction. The generated deaminated products are potentially mutagenic because of their structural similarity to natural bases, which in turn leads
Isao Kuraoka
doaj   +1 more source

Targeting G-quadruplex motifs interferes with differentiation of adipose-derived mesenchymal stem cells

Stem Cell Research & Therapy, 2023
Background G-quadruplex (G4) motifs are nucleic acid secondary structures observed in mammalian genomes and transcriptomes able to regulate various cellular processes.
Maria Rosaria Ambrosio, Teresa Migliaccio, Fabiana Napolitano, Sarah Di Somma, Giovanni Maneli, Jussara Amato, Bruno Pagano, Antonio Randazzo, Giuseppe Portella, Pietro Formisano, Anna Maria Malfitano   +10 more
doaj   +1 more source

A New Perspective on the Antimicrobial Mechanism of Berberine Hydrochloride Against Staphylococcus aureus Revealed by Untargeted Metabolomic Studies

Frontiers in Microbiology, 2022
Berberine hydrochloride (BBR) is a natural product widely used in clinical medicine and animal production. It has a variety of antimicrobial effects, but its complex antimicrobial mechanism has not been clarified.
Shu Wu, Kun Yang, Yuhang Hong, Yanju Gong, Jiajia Ni, Jiajia Ni, Ni Yang, Weijun Ding   +7 more
doaj   +1 more source

Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp. isolated from Euphorbia characias

Memorias do Instituto Oswaldo Cruz, 2004
There is no effective chemotherapy against diseases caused by Phytomonas sp., a plant trypanosomatid responsible for economic losses in major crops.
Rosa Magán, Clotilde Marín, Juan M Salas, Mario Barrera-Pérez, Maria J Rosales, Manuel Sánchez-Moreno   +5 more
doaj   +1 more source

Modification of Purine and Pyrimidine Nucleosides by Direct C-H Bond Activation

Molecules, 2015
Transition metal-catalyzed modifications of the activated heterocyclic bases of nucleosides as well as DNA or RNA fragments employing traditional cross-coupling methods have been well-established in nucleic acid chemistry.
Yong Liang, Stanislaw F. Wnuk
doaj   +1 more source