Results 41 to 50 of about 3,173,825 (322)

Novel Selenium-modified Nucleic Acids For Structural and Functional Studies [PDF]

, 2015
Nucleic acids, as one of the most important macromolecules in living systems, play critical roles in storing, transferring, regulating genetic information, directing proteins synthesis, and catalysis. Understanding the structure of nucleic acid can bring
Jiang, Sibo
core   +1 more source

Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp. isolated from Euphorbia characias

Memorias do Instituto Oswaldo Cruz, 2004
There is no effective chemotherapy against diseases caused by Phytomonas sp., a plant trypanosomatid responsible for economic losses in major crops.
Rosa Magán, Clotilde Marín, Juan M Salas, Mario Barrera-Pérez, Maria J Rosales, Manuel Sánchez-Moreno   +5 more
doaj   +1 more source

Phase Characterization and Bioactivity Evaluation of Nucleic Acid-Encapsulated Biomimetically Mineralized ZIF-8.

ACS Applied Materials and Interfaces
Metal-organic frameworks (MOFs) provide diverse applications across a wide range of scientific disciplines, including drug/nucleic acid (NA) delivery.
S. A. Polash, A. Poddar, S. Pyreddy, F. Carraro, Anita M. D’Angelo, G. Bryant, P. Falcaro, Ravi Shukla   +7 more
semanticscholar   +1 more source

Targeting G-quadruplex motifs interferes with differentiation of adipose-derived mesenchymal stem cells

Stem Cell Research & Therapy, 2023
Background G-quadruplex (G4) motifs are nucleic acid secondary structures observed in mammalian genomes and transcriptomes able to regulate various cellular processes.
Maria Rosaria Ambrosio, Teresa Migliaccio, Fabiana Napolitano, Sarah Di Somma, Giovanni Maneli, Jussara Amato, Bruno Pagano, Antonio Randazzo, Giuseppe Portella, Pietro Formisano, Anna Maria Malfitano   +10 more
doaj   +1 more source

Decoding Mycoplasma Nucleases: Biological Functions and Pathogenesis

Toxins
Nucleases are critical metabolic enzymes expressed by mycoplasmas to acquire nucleic acid precursors from the host for their parasitic existence. Certain nucleases, either membrane-bound or secreted, not only contribute to the growth of mycoplasmas but ...
Xinchao Yi, Ying Huang, Xinru Li, Hao Xu, Chang Liu, Chao Li, Qianrui Zeng, Haodang Luo, Zufeng Ye, Jun He, Xiaoxing You   +10 more
doaj   +1 more source

Modification of Purine and Pyrimidine Nucleosides by Direct C-H Bond Activation

Molecules, 2015
Transition metal-catalyzed modifications of the activated heterocyclic bases of nucleosides as well as DNA or RNA fragments employing traditional cross-coupling methods have been well-established in nucleic acid chemistry.
Yong Liang, Stanislaw F. Wnuk
doaj   +1 more source

A New Perspective on the Antimicrobial Mechanism of Berberine Hydrochloride Against Staphylococcus aureus Revealed by Untargeted Metabolomic Studies

Frontiers in Microbiology, 2022
Berberine hydrochloride (BBR) is a natural product widely used in clinical medicine and animal production. It has a variety of antimicrobial effects, but its complex antimicrobial mechanism has not been clarified.
Shu Wu, Kun Yang, Yuhang Hong, Yanju Gong, Jiajia Ni, Jiajia Ni, Ni Yang, Weijun Ding   +7 more
doaj   +1 more source

Non‐enzymatic glycolysis and pentose phosphate pathway‐like reactions in a plausible Archean ocean

Molecular Systems Biology, 2014
The reaction sequences of central metabolism, glycolysis and the pentose phosphate pathway provide essential precursors for nucleic acids, amino acids and lipids. However, their evolutionary origins are not yet understood.
Markus A Keller, Alexandra V Turchyn, Markus Ralser   +2 more
doaj   +1 more source

Defects in germinal center selection in SLE

Frontiers in Immunology, 2015
Germinal centers (GCs) are the primary site at which clonal expansion and affinity maturation of B cells occurs. B cells encounter antigen and receive T cell help in the GC light zone (LZ) and then migrate to the dark zone where they proliferate and ...
Megan eWoods, Yong-Rui eZou, Anne eDavidson   +2 more
doaj   +1 more source

Stochastic Simulation of the Kinetics of Multiple Interacting Nucleic Acid Strands [PDF]

, 2013
DNA nanotechnology is an emerging field which utilizes the unique structural properties of nucleic acids in order to build nanoscale devices, such as logic gates, motors, walkers, and algorithmic structures. Predicting the structure and interactions of a
Schaeffer, Joseph Malcolm
core   +1 more source